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Literature summary for 3.1.4.17 extracted from

  • Chan, A.L.; Huang, H.L.; Chien, H.C.; Chen, C.M.; Lin, C.N.; Ko, W.C.
    Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [3H]-rolipram binding in guinea pig tissues (2008), Invest. New Drugs, 26, 417-424.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone Ro20-1724 Cavia porcellus
cGMP
-
Cavia porcellus
Milrinone
-
Cavia porcellus
quercetin
-
Cavia porcellus
quercetin-3,5,7,3',4'-O-pentaacetate
-
Cavia porcellus
quercetin-3,5,7,3',4'-O-pentamethylether
-
Cavia porcellus
quercetin-3,7,3',4'-O-tetramethylether
-
Cavia porcellus
quercetin-3,7,4'-O-trimethylether ayanin Cavia porcellus
quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate
-
Cavia porcellus
quercetin-3-O-methylether
-
Cavia porcellus
rolipram
-
Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially purified by Q-Sepharose column chromatography Cavia porcellus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside 3',5'-cyclic phosphate + H2O
-
Cavia porcellus nucleoside 5'-phosphate
-
?

Synonyms

Synonyms Comment Organism
PDE3
-
Cavia porcellus
phosphodiesterase-3
-
Cavia porcellus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0008
-
PDE3 Cavia porcellus quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate
0.0016
-
PDE3 Cavia porcellus quercetin-3-O-methylether
0.002
-
PDE3 Cavia porcellus Milrinone
0.002
-
PDE3 Cavia porcellus quercetin-3,5,7,3',4'-O-pentaacetate
0.0041
-
PDE3 Cavia porcellus quercetin-3,7,4'-O-trimethylether
0.0047
-
PDE3 Cavia porcellus quercetin-3,5,7,3',4'-O-pentamethylether
0.0056
-
PDE3 Cavia porcellus quercetin
0.0228
-
PDE3 Cavia porcellus quercetin-3,7,3',4'-O-tetramethylether
0.0869
-
PDE3 Cavia porcellus quercetin-3-O-methylether