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Literature summary for 3.1.4.17 extracted from

  • Siuciak, J.A.
    The role of phosphodiesterases in schizophrenia: therapeutic implications (2008), CNS Drugs, 22, 983-993.
    View publication on PubMed
Search for more literature for 3.1.4.17

Inhibitors

Inhibitors Comment Organism Structure
dipyridamole inhibits with micromolar potency Homo sapiens
dipyridamole inhibits with micromolar potency Rattus norvegicus
isobutylmethylxanthine inhibits with micromolar potency Homo sapiens
isobutylmethylxanthine inhibits with micromolar potency Rattus norvegicus
MP-10
-
 Homo sapiens
papaverine competitive inhibitor Homo sapiens
papaverine competitive inhibitor Rattus norvegicus
PQ-10
-
 Homo sapiens
TP-10
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain PDE10A is strongly expressed in the brain, highly expressed in striatal complex including caudate putamen, nucleus accumbens, and olfacory tubercle Homo sapiens
-
brain PDE10A is strongly expressed in the brain, highly expressed in striatal complex including caudate putamen, nucleus accumbens, and olfacory tubercle Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?
3',5'-cAMP + H2O
-
 Rattus norvegicus 5'-AMP
-
 ?
3',5'-cGMP + H2O
-
 Homo sapiens 5'-GMP
-
 ?
3',5'-cGMP + H2O
-
 Rattus norvegicus 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
PDE10A hydrolyses both 3',5'-cAMP and 3',5'-cGMP although with different kinetic parameters Homo sapiens
PDE10A hydrolyses both 3',5'-cAMP and 3',5'-cGMP although with different kinetic parameters Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000036
-
-
 Rattus norvegicus papaverine