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Literature summary for 3.1.4.17 extracted from

  • Bader, S.; Kortholt, A.; Van Haastert, P.J.
    Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP (2007), Biochem. J., 402, 153-161.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.17

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0002
-
 cGMP isoform PDE3, 22°C, pH 7.0 Dictyostelium discoideum
0.00075
-
 cAMP isoform PDE1, 22°C, pH 7.0 Dictyostelium discoideum
0.005
-
 cAMP isoform PDE2, 22°C, pH 7.0 Dictyostelium discoideum
0.0125
-
 cAMP isoform PDE7, 22°C, pH 7.0 Dictyostelium discoideum

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
 isoforms PDE1, PDE2, PDE3, PDE7
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cAMP + H2O degradation of extracellular cAMP by isoforms PDE1, PDE7. Degradation of intracellular cAMP by isoform PDE2 Dictyostelium discoideum 5'-AMP
-
 ?
cGMP + H2O degradation of intracellular cGMP by isoform PDE3 Dictyostelium discoideum 5'-GMP
-
 ?
additional information isoforms PDE1 and PDE7 are dual-specificity enzymes with negative cooperativity and very different kinetics. Both have 2-3fold lower affinity for cGMP than for cAMP Dictyostelium discoideum ?
-
 ?