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Literature summary for 3.1.4.17 extracted from

  • Yuasa, K.; Ohgaru, T.; Asahina, M.; Omori, K.
    Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A). Comparison of rat and human PDE11A splicing variants (2001), Eur. J. Biochem., 268, 4440-4448.
    View publication on PubMed
Search for more literature for 3.1.4.17

Inhibitors

Inhibitors Comment Organism Structure
5-(3-cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one 50% inhibition at about 0.1 mM Rattus norvegicus
dipyridamole 50% inhibition at about 0.0002-0.00055 mM Rattus norvegicus
E4021 50% inhibition at about 0.0005-0.001 mM Rattus norvegicus
erythro-9-(2-hydroxy-3-nonyl)adenine 50% inhibition at about 0.1 mM Rattus norvegicus
isobutylmethylxanthine 50% inhibition at about 0.05 mM Rattus norvegicus
Milrinone 50% inhibition at about 0.1 mM Rattus norvegicus
vinpocetine 50% inhibition at about 0.06-0.09 mM Rattus norvegicus
zaprinast 50% inhibition at about 0.016-0.02 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0013 0.0016 cGMP
-
 Rattus norvegicus
0.002 0.004 cAMP
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 isozyme PDE11A
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information tissue-specific expression of splice-variants Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cAMP + H2O
-
 Rattus norvegicus AMP
-
 ?
cGMP + H2O
-
 Rattus norvegicus GMP
-
 ?