Literature summary for 3.1.4.11 extracted from

Stewart, A.J.; Mukherjee, J.; Roberts, S.J.; Lester, D.; Farquharson, C.
Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes (2005), Int. J. Mol. Med., 15, 117-121.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	PLC-eta enzymes may function in the membrane-mediated signaling cascade through intracellular Ca2+ and protein kinase C pathways	?	-	?
additional information	Homo sapiens	PLC-eta enzymes may function in the membrane-mediated signaling cascade through intracellular Ca2+ and protein kinase C pathways	?	-	?

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue	Comment	Organism	Textmining
anaplastic oligodendroglioma cell	anaplastic, PLC-eta2	Homo sapiens	-
anaplastic oligodendroglioma cell	PLC-eta2	Homo sapiens	-
brain	PLC-eta1	Mus musculus	-
brain	PLC-eta2	Mus musculus	-
colon	PLC-eta1	Homo sapiens	-
embryonic stem cell	PLC-eta1	Homo sapiens	-
eye	PLC-eta1	Mus musculus	-
head	upper head, PLC-eta1	Mus musculus	-
kidney	PLC-eta1	Mus musculus	-
lymph	PLC-eta1	Homo sapiens	-
lymph	PLC-eta2	Homo sapiens	-
nerve tumor cell	PLC-eta1	Homo sapiens	-
nerve tumor cell	PLC-eta2	Homo sapiens	-
neural retina	PLC-eta1	Mus musculus	-
optic nerve	PLC-eta1	Homo sapiens	-
optic nerve	PLC-eta2	Homo sapiens	-
pancreatic islet	PLC-eta1	Homo sapiens	-
pancreatic islet	PLC-eta2	Homo sapiens	-
pituitary gland	PLC-eta1	Homo sapiens	-
pituitary gland	PLC-eta2	Homo sapiens	-
retinoblastoma cell	PLC-eta1	Homo sapiens	-
retinoblastoma cell	PLC-eta2	Homo sapiens	-
teratocarcinoma cell	PLC-eta1	Homo sapiens	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	-	Mus musculus	1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol	-	?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	-	Homo sapiens	1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol	-	?
additional information	PLC-eta enzymes may function in the membrane-mediated signaling cascade through intracellular Ca2+ and protein kinase C pathways	Mus musculus	?	-	?
additional information	PLC-eta enzymes may function in the membrane-mediated signaling cascade through intracellular Ca2+ and protein kinase C pathways	Homo sapiens	?	-	?