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Literature summary for 3.1.4.1 extracted from

  • Fehr, M.; Baechler, S.; Kropat, C.; Mielke, C.; Boege, F.; Pahlke, G.; Marko, D.
    Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1 (2010), Mycotoxin Res., 26, 247-256.
    View publication on PubMed
Search for more literature for 3.1.4.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293 cells and HCT116 cells, quantitative real-time RT-PCR expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression and suppression of the enzyme in HCT116 cells, increased alternariol-mediated rate of DNA strand breaks in TDP1-suppressed HCT116 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell vulva carcinoma cells Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the active site H263 is covalently bound through a phosphoamide bond to the 3' end of DNA moiety of the substrate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TDP1
-
 Homo sapiens
tyrosyl-DNA phosphodiesterase 1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function tyrosyl-DNA phosphodiesterase 1 is an enzyme vital to the repair of covalent DNA-topoisomerase adducts, e.g. induced by the mycotoxin alternariol, it affects alternariol-mediated genotoxicity. TDP1 plays an important role in the repair of topoisomerase-mediated DNA damage. The repair enzyme TDP1 is a factor for the modulation of AOH-mediated DNA damage in human cells. TDP1 is also involved in the repair of topoisomerase II-induced DNA damage Homo sapiens