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Literature summary for 3.1.3.53 extracted from

  • Belik, J.; Majumdar, R.; Fabris, V.E.; Kerc, E.; Pato, M.D.
    Myosin light chain phosphatase and kinase abnormalities in fetal sheep pulmonary hypertension (1998), Pediatr. Res., 43, 57-61.
    View publication on PubMed
Search for more literature for 3.1.3.53

Inhibitors

Inhibitors Comment Organism Structure
additional information pulmonary hypertension down-regulates pulmonary vascular MLCP expression Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Ovis aries pulmonary hypertension down-regulates pulmonary vascular MLCP expression, the maintenance of a high pulmonary vascular resistance may be secondary to abnormalities in tissue content and/or activity of MLCP ?
-
 ?
myosin light-chain phosphate + H2O Ovis aries key smooth muscle regulatory protein, MLCP is required for muscle relaxation myosin light-chain + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Ovis aries
-
 normal and pulmonary hypertensive fetal sheep, MLCP, protein phosphatase type 1
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta fetal, same MLCP activities in normal and pulmonary hypertensive fetal sheep Ovis aries
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fetus normal and pulmonary hypertensive fetal sheep, pulmonary artery, aorta and vena cava Ovis aries
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pulmonary artery fetal, MLCP activity in pulmonary hypertensive fetal sheep is significantly lower than in normal fetal sheep Ovis aries
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vena cava fetal, same MLCP activities in normal and pulmonary hypertensive fetal sheep Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information pulmonary hypertension down-regulates pulmonary vascular MLCP expression, the maintenance of a high pulmonary vascular resistance may be secondary to abnormalities in tissue content and/or activity of MLCP Ovis aries ?
-
 ?
myosin light-chain phosphate + H2O from turkey gizzard Ovis aries myosin light-chain + phosphate
-
 ?
myosin light-chain phosphate + H2O 20 kDa myosin light chain Ovis aries myosin light-chain + phosphate
-
 ?
myosin light-chain phosphate + H2O key smooth muscle regulatory protein, MLCP is required for muscle relaxation Ovis aries myosin light-chain + phosphate
-
 ?
phosphorylated heavy meromyosin + H2O from turkey gizzard Ovis aries heavy meromyosin + phosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Ovis aries

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Ovis aries