Application | Comment | Organism |
---|---|---|
drug development | MptpB is a promising target for development of anti-tuberculosis drugs | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | development of a rapid high-throughput screening method for PTP inhibitors, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
paxilin tyrosine phosphate + H2O | Homo sapiens | PTPRT specifically regulates paxillin phosphorylation at Tyr88 in colorectal cancer cells | paxilin tyrosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | - |
Homo sapiens | - |
colorectal cancer cell | - |
Homo sapiens | - |
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
paxilin tyrosine phosphate + H2O | PTPRT specifically regulates paxillin phosphorylation at Tyr88 in colorectal cancer cells | Homo sapiens | paxilin tyrosine + phosphate | - |
? | |
paxilin tyrosine phosphate + H2O | substrate of PTPRT, inactive with paxilin mutant Y88F | Homo sapiens | paxilin tyrosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Protein tyrosine phosphatase receptor-type T | - |
Homo sapiens |
PTPRT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | CRC cells homozygous for a paxillin Y88F knock-in mutant exhibit significantly reduced cell migration and impaired anchorage-independent growth, and they fail to form xenograft tumors in nude mice, and have decreased phosphorylation of p130CAS, SHP2, and AKT | Homo sapiens |
physiological function | PTPRT is involved in important signaling pathway that plays a critical role in colorectal tumorigenesis, overview | Homo sapiens |