Protein Variants | Comment | Organism |
---|---|---|
C649S | construction of a myc-tagged PTP3DELTAC649S mutant | Dictyostelium discoideum |
additional information | overexpression of PTP3 inhibits nuclear accumulation of STATc at the slug stage | Dictyostelium discoideum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Differentiation inducing factor 1 | DIF-1, inhibits PTP3 by induction of serine-threonine phosphorylation of PTP3 | Dictyostelium discoideum | |
additional information | hyperosmotic stress inhibits PTP3. Overexpression of a dominant inhibitor of PTP3 leads to constitutive tyrosine phosphorylation and ectopic nuclear localisation of STATc | Dictyostelium discoideum | |
pervanadate | - |
Dictyostelium discoideum | |
sorbitol | - |
Dictyostelium discoideum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Dictyostelium discoideum | STATc becomes tyrosine phosphorylated and accumulates in the nucleus when Dictyostelium cells are exposed to the prestalk cell inducer Differentiation inducing factor 1, DIF-1, or are subjected to hyperosmotic stress | ? | - |
? | |
phosphorylated STAT1c + H2O | Dictyostelium discoideum | mode of STAT activation, whereby serine-threonine phosphorylation of the cognate protein tyrosine phosphatase PTP3 results in the inhibition of its activity, shifting the phosphorylation-dephosphorylation equilibrium in favour of phosphorylation, overview | STAT1c + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium discoideum | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | serine-threonine phosphorylation inhibits PTP3, is induced by DIF-1 | Dictyostelium discoideum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AX-2 cell | - |
Dictyostelium discoideum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Dictyostelium discoideum | 4-nitrophenol + phosphate | - |
? | |
additional information | STATc becomes tyrosine phosphorylated and accumulates in the nucleus when Dictyostelium cells are exposed to the prestalk cell inducer Differentiation inducing factor 1, DIF-1, or are subjected to hyperosmotic stress | Dictyostelium discoideum | ? | - |
? | |
phosphorylated STAT1c + H2O | - |
Dictyostelium discoideum | STAT1c + phosphate | - |
? | |
phosphorylated STAT1c + H2O | mode of STAT activation, whereby serine-threonine phosphorylation of the cognate protein tyrosine phosphatase PTP3 results in the inhibition of its activity, shifting the phosphorylation-dephosphorylation equilibrium in favour of phosphorylation, overview | Dictyostelium discoideum | STAT1c + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Dictyostelium discoideum |
PTP3 | - |
Dictyostelium discoideum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at, substrate 4-nitrophenyl phosphate | Dictyostelium discoideum |