Inhibitors | Comment | Organism | Structure |
---|---|---|---|
((1E)-2-nitroprop-1-en-1-yl)benzene | 50% inhibition at 0.023 mM in absence of 2-mercaptoethanol, at 0.515 mM in presence of 1 mM 2-mercaptoethanol | Homo sapiens | |
((E)-2-nitrovinyl)benzene | i.e. trans-beta-nitrostyrene, slow-binding inhibitor, acting as a pY mimetic and binding to the enzyme active site to form an initial noncovalent E*I complex, followed by nucleophilic attack on the nitrostyrene nitro group by C215 of enzyme to form a reversible, covalent adduct. 50% inhibition at 0.0025 mM in absence of 2-mercaptoethanol, at 0.4 mM in presence of 1 mM 2-mercaptoethanol | Homo sapiens | |
1,3-difluoro-2-[(E)-2-nitroethenyl]benzene | 50% inhibition at 0.0048 mM in absence of 2-mercaptoethanol, at 0.34 mM in presence of 1 mM 2-mercaptoethanol | Homo sapiens | |
1-methoxy-4-((E)-2-nitrovinyl)benzene | 50% inhibition at 0.0045 mM in absence of 2-mercaptoethanol, at 0.27 mM in presence of 1 mM 2-mercaptoethanol | Homo sapiens | |
1-methyl-4-((E)-2-nitrovinyl)benzene | 50% inhibition at 0.003 mM in absence of 2-mercaptoethanol, at 0.225 mM in presence of 1 mM 2-mercaptoethanol | Homo sapiens | |
2,4-dimethoxy-1-((E)-2-nitrovinyl)benzene | 50% inhibition at 0.028 mM in absence of 2-mercaptoethanol, at 0.390 mM in presence of 1 mM 2-mercaptoethanol | Homo sapiens | |
4-((E)-2-nitrovinyl)benzoic acid | 50% inhibition at 0.0027 mM in absence of 2-mercaptoethanol, at 0.425 mM in presence of 1 mM 2-mercaptoethanol | Homo sapiens | |
N-((4-((E)-2-nitroethenyl)phenyl)carbonyl)glycyl-L-alpha-glutamyl-L-glutamic acid | 50% inhibition at 0.0014 mM in absence of 2-mercaptoethanol, at 0.275 mM in presence of 1 mM 2-mercaptoethanol | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform PTP1B, recombinant enzyme | - |