Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-ethyl-6-methyl-3-phenyl-1H-pyrimido(5,4-e)(1,2,4)triazine-5,7-dione | covalent mode of action | Homo sapiens | |
1-ethyl-6-methyl-3-phenyl-1H-pyrimido(5,4-e)(1,2,4)triazine-5,7-dione | covalent mode of action | Yersinia sp. | |
2,2-dioxo-2,3-dihydro-2-OMEGA-16-benzo (1,2,3)oxathiazole-6-carboxylic acid (5-phenylsulfanyl-1H-benzoimidazol-2-ylmethyl)-amide | competitive, noncovalent mode of action | Homo sapiens | |
2,2-dioxo-2,3-dihydro-2-OMEGA-16-benzo (1,2,3)oxathiazole-6-carboxylic acid (5-phenylsulfanyl-1H-benzoimidazol-2-ylmethyl)-amide | competitive, noncovalent mode of action | Yersinia sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0029 | - |
insulin receptor phosphopeptide | isoform PTP1B, 37°C, pH 6.9 | Homo sapiens | |
0.02 | - |
4,6,8-trimethyl-2-oxo-2H-chromen-7-yl dihydrogen phosphate | isoform PTP1B, 37°C, pH 6.9 | Homo sapiens | |
0.115 | - |
4,6,8-trimethyl-2-oxo-2H-chromen-7-yl dihydrogen phosphate | 37°C, pH 6.9 | Yersinia sp. | |
0.156 | - |
4,6,8-trimethyl-2-oxo-2H-chromen-7-yl dihydrogen phosphate | isoform CD45, 37°C, pH 6.9 | Homo sapiens | |
1.4 | - |
4-nitrophenyl phosphate | isoform PTP1B, 37°C, pH 6.9 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoforms PTP1B, CD45, comercial preparations | - |
Yersinia sp. | - |
isoform YOP, comercial preparation | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
continuous and highly specific assay method based on substrate 6,8-difluoro-4-methylumbiliferyl phosphate | Homo sapiens |
additional information | - |
continuous and highly specific assay method based on substrate 6,8-difluoro-4-methylumbiliferyl phosphate | Yersinia sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? | |
4-nitrophenyl phosphate + H2O | - |
Yersinia sp. | 4-nitrophenol + phosphate | - |
? | |
6,8-difluoro-4-methylumbelliferyl phosphate + H2O | - |
Homo sapiens | 6,8-difluoro-4-methylumbelliferone + phosphate | - |
? | |
6,8-difluoro-4-methylumbelliferyl phosphate + H2O | - |
Yersinia sp. | 6,8-difluoro-4-methylumbelliferone + phosphate | - |
? | |
insulin receptor phosphopeptide + H2O | - |
Homo sapiens | insulin receptor peptide + phosphate | - |
? | |
insulin receptor phosphopeptide + H2O | - |
Yersinia sp. | insulin receptor peptide + phosphate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2 | - |
4,6,8-trimethyl-2-oxo-2H-chromen-7-yl dihydrogen phosphate | isoform CD45, 37°C, pH 6.9 | Homo sapiens | |
16.8 | - |
4,6,8-trimethyl-2-oxo-2H-chromen-7-yl dihydrogen phosphate | isoform PTP1B, 37°C, pH 6.9 | Homo sapiens | |
27.5 | - |
4-nitrophenyl phosphate | isoform PTP1B, 37°C, pH 6.9 | Homo sapiens | |
36.7 | - |
4,6,8-trimethyl-2-oxo-2H-chromen-7-yl dihydrogen phosphate | 37°C, pH 6.9 | Yersinia sp. | |
61.5 | - |
insulin receptor phosphopeptide | isoform PTP1B, 37°C, pH 6.9 | Homo sapiens | |
71.6 | - |
4,6,8-trimethyl-2-oxo-2H-chromen-7-yl dihydrogen phosphate | isoform CD45, 37°C, pH 6.9 | Homo sapiens |