Protein Variants | Comment | Organism |
---|---|---|
C258M | isoform PTP1B, mutation turns 1B isoform to PTPalpha-like enzyme in substrate recognition | Homo sapiens |
D48N | isoform PTP1B, mutation turns 1B isoform to PTPalpha-like enzyme in substrate recognition | Homo sapiens |
G259Q | isoform PTP1B, mutation turns 1B isoform to PTPalpha-like enzyme in substrate recognition | Homo sapiens |
M258C | isoform PTPalpha, mutation turns alpha isoform to PTP1B-like enzyme in substrate recognition | Homo sapiens |
N48D | isoform PTPalpha, mutation turns alpha isoform to PTP1B-like enzyme in substrate recognition | Homo sapiens |
Q259G | isoform PTPalpha, mutation turns alpha isoform to PTP1B-like enzyme in substrate recognition | Homo sapiens |
R47V | isoform PTP1B, mutation turns 1B isoform to PTPalpha-like enzyme in substrate recognition | Homo sapiens |
V47R | isoform PTPalpha, mutation turns alpha isoform to PTP1B-like enzyme in substrate recognition | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0228 | - |
acetyl-DADEpY-NH2 | pH 5.5, 30°C, PTP1B | Homo sapiens | |
0.0246 | - |
acetyl-DADEpY-NH2 | pH 5.5, 30°C, PTP1B, mutants R47V, D48N | Homo sapiens | |
0.0424 | - |
acetyl-DADEpY-NH2 | pH 5.5, 30°C, PTP1B, mutants M258C, G259Q | Homo sapiens | |
0.219 | - |
acetyl-DADEpY-NH2 | pH 5.5, 30°C, PTPalpha | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes PTP1B, PTPalpha | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate | mechanism | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-DADEpY-NH2 + H2O | - |
Homo sapiens | acetyl-DADEY-NH2 + phosphate | - |
? | |
additional information | kinetic constants for several peptide substrates | Homo sapiens | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
2 | - |
2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid | pH 5.5, 25°C, isozyme PTP1B | Homo sapiens | |
19 | - |
2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid | pH 5.5, 25°C, isozyme PTPalpha, mutant Q259G | Homo sapiens | |
33 | - |
2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid | pH 5.5, 25°C, isozyme PTP1B, mutant G259Q | Homo sapiens | |
81 | - |
2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid | pH 5.5, 25°C, isozyme PTPalpha | Homo sapiens |