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Literature summary for 3.1.3.4 extracted from

  • Brindley, D.N.
    Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer (2004), J. Cell. Biochem., 92, 900-912.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information treatment of HeLa cells with the epidermal growth factor leads to 3fold increased LPP-3 expression, while LPP-1 expression is unaffected, LPP-1 expression is increased in prostate adenocarcinoma cells treated with androgens Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of LPP-3 in HEK293 cells and in Xenopus laevis dorsal blastomeres of embryos causing a mild ventralizing effect Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of several mouse models overexpressing or lacking LPP isozymes, e.g. overexpression of LPP-1 leads to defects in fertility in female mice and to increased accumulation of diacylglycerol, LPP-2 knockout mice are fertile and viable, whereas LPP-3 knockout mice show a severe phenotype failing to form a chorio-allantoic placenta and yolk sac vasculature, in addition, mutant embryos show a shortening of the anterior-posterior axis, overview, introduction of LPP-1 into Drosophila melanogaster germ cells has no effect on the germ-cell-specific factor in vivo Mus musculus
additional information introduction of LPP-3 into Drosophila melanogaster germ cells causes aberrant migration and germ cell death Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the enzymes act intra- and extracellularly Drosophila melanogaster
-
-
additional information the enzymes act intra- and extracellularly Mus musculus
-
-
additional information the enzymes act intra- and extracellularly Rattus norvegicus
-
-
additional information the enzymes act intra- and extracellularly Homo sapiens
-
-
plasma membrane
-
Mus musculus 5886
-
plasma membrane
-
Rattus norvegicus 5886
-
plasma membrane isozyme LPP-1, containing the apical sorting signal FDKTRL, is mainly located at the apical surface membrane, while isozyme LPP-3 is located at the basolateral membrane being targeted by the dityrosine motif in the second cytoplasmic portion Homo sapiens 5886
-
plasma membrane the isozyme LPP-1 is partly expressed in the plama membrane with its C-terminal end located on the cell surface Drosophila melanogaster 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lysophosphatidic acid + H2O Drosophila melanogaster
-
monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O Mus musculus
-
monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O Rattus norvegicus
-
monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O Homo sapiens
-
monoacylglycerol + phosphate
-
?
additional information Homo sapiens LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, LPP-3 is involved in embryonal axis patterning, overview ?
-
?
additional information Mus musculus LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview ?
-
?
additional information Rattus norvegicus LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview ?
-
?
additional information Homo sapiens LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview ?
-
?
additional information Drosophila melanogaster LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, Wunen and Wunen2 are essential for germ cell development, overview ?
-
?
additional information Homo sapiens LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, overview, expression of PRG-1 in neurons increases extracellular lysophosphatidic acid breakdown and attenuates LPA-induced axonal retraction, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview ?
-
?
sphingosine 1-phosphate + H2O Drosophila melanogaster
-
sphingosine + phosphate
-
?
sphingosine 1-phosphate + H2O Mus musculus
-
sphingosine + phosphate
-
?
sphingosine 1-phosphate + H2O Rattus norvegicus
-
sphingosine + phosphate
-
?
sphingosine 1-phosphate + H2O Homo sapiens
-
sphingosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
genes Wun and Wun2
-
Homo sapiens Q6T4P5 LPR-3; LPR-3
-
Homo sapiens Q7Z2D5 PRG-1 or LPR-4; PRG-1 or LPR-4
-
Homo sapiens Q8TBJ4 PRG-3 or LPR-1; isozyme PRG-3 or LPR-1
-
Homo sapiens Q96GM1 LPR-2 or PRG-4; PRG-4 or LPR-2
-
Mus musculus
-
several isozymes, e.g. isozyme PAP2A, i.e. LPP-1
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-glycosylation Drosophila melanogaster
glycoprotein N-glycosylation Mus musculus
glycoprotein N-glycosylation Rattus norvegicus
glycoprotein N-glycosylation Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate the active site of plasma membrane LPP-1, LPP-2, and LPP-3 is outside the cell, the conserved phosphatase family amino acids are essential for catalytic activity Drosophila melanogaster

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Homo sapiens
-
bladder
-
Homo sapiens
-
brain
-
Homo sapiens
-
brain LPP-2 predominantly Homo sapiens
-
heart
-
Homo sapiens
-
heart LPP-1a predominantly Homo sapiens
-
HeLa cell
-
Homo sapiens
-
intestinal mucosa epithelial differentiation of intestinal mucosa leads to increased Dri-42/LPP-3 expression Rattus norvegicus
-
kidney
-
Homo sapiens
-
kidney LPP-1 predominantly Homo sapiens
-
liver
-
Homo sapiens
-
liver LPP-1 predominantly Homo sapiens
-
lung
-
Homo sapiens
-
lung LPP-1 predominantly Homo sapiens
-
additional information tissue distribution Homo sapiens
-
neuron expression of PRG-1 Homo sapiens
-
pancreas
-
Homo sapiens
-
pancreas LPP-2 predominantly Homo sapiens
-
placenta
-
Homo sapiens
-
placenta LPP-1 predominantly Homo sapiens
-
placenta LPP-2 predominantly Homo sapiens
-
prostate adenocarcinoma cell LPP-1 Homo sapiens
-
prostate gland
-
Homo sapiens
-
uterus
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide 1-phosphate + H2O
-
Drosophila melanogaster ceramide + phosphate
-
?
ceramide 1-phosphate + H2O
-
Mus musculus ceramide + phosphate
-
?
ceramide 1-phosphate + H2O
-
Rattus norvegicus ceramide + phosphate
-
?
ceramide 1-phosphate + H2O
-
Homo sapiens ceramide + phosphate
-
?
lysophosphatidic acid + H2O
-
Drosophila melanogaster monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O
-
Mus musculus monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O
-
Rattus norvegicus monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O
-
Homo sapiens monoacylglycerol + phosphate
-
?
additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, LPP-3 is involved in embryonal axis patterning, overview Homo sapiens ?
-
?
additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview Mus musculus ?
-
?
additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview Rattus norvegicus ?
-
?
additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview Homo sapiens ?
-
?
additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, Wunen and Wunen2 are essential for germ cell development, overview Drosophila melanogaster ?
-
?
additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, overview, expression of PRG-1 in neurons increases extracellular lysophosphatidic acid breakdown and attenuates LPA-induced axonal retraction, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview Homo sapiens ?
-
?
additional information Wunen does not interact with Wunen2 Drosophila melanogaster ?
-
?
phosphatidic acid + H2O
-
Drosophila melanogaster diacylglycerol + phosphate
-
?
phosphatidic acid + H2O
-
Mus musculus diacylglycerol + phosphate
-
?
phosphatidic acid + H2O
-
Rattus norvegicus diacylglycerol + phosphate
-
?
phosphatidic acid + H2O
-
Homo sapiens diacylglycerol + phosphate
-
?
sphingosine 1-phosphate + H2O
-
Drosophila melanogaster sphingosine + phosphate
-
?
sphingosine 1-phosphate + H2O
-
Mus musculus sphingosine + phosphate
-
?
sphingosine 1-phosphate + H2O
-
Rattus norvegicus sphingosine + phosphate
-
?
sphingosine 1-phosphate + H2O
-
Homo sapiens sphingosine + phosphate
-
?

Subunits

Subunits Comment Organism
More the LPPs contain three conserved active site domains and six conserved transmembrane domains Drosophila melanogaster

Synonyms

Synonyms Comment Organism
Dri-42 i.e. LPP-3 Rattus norvegicus
lipid phosphate phosphatase
-
Drosophila melanogaster
lipid phosphate phosphatase
-
Mus musculus
lipid phosphate phosphatase
-
Rattus norvegicus
lipid phosphate phosphatase
-
Homo sapiens
lipid phosphate phosphatase-related protein
-
Drosophila melanogaster
lipid phosphate phosphatase-related protein
-
Mus musculus
lipid phosphate phosphatase-related protein
-
Rattus norvegicus
lipid phosphate phosphatase-related protein type 1
-
Homo sapiens
lipid phosphate phosphatase-related protein type 2
-
Homo sapiens
lipid phosphate phosphatase-related protein type 3
-
Homo sapiens
lipid phosphate phosphatase-related protein type 4
-
Homo sapiens
LPP
-
Drosophila melanogaster
LPP
-
Mus musculus
LPP
-
Rattus norvegicus
LPP
-
Homo sapiens
LPPR2
-
Homo sapiens
LPR
-
Drosophila melanogaster
LPR
-
Mus musculus
LPR
-
Rattus norvegicus
LPR-1
-
Homo sapiens
LPR-2
-
Homo sapiens
LPR-3
-
Homo sapiens
LPR-4
-
Homo sapiens
PAP
-
Mus musculus
plasticity related gene 1
-
Homo sapiens
plasticity related gene 3
-
Homo sapiens
plasticity related gene 4
-
Homo sapiens
PRG-1
-
Homo sapiens
PRG-3
-
Homo sapiens
Wunen
-
Drosophila melanogaster
Wunen2
-
Drosophila melanogaster