Cloned (Comment) | Organism |
---|---|
genes impA and impC, genetic analysis of the four IMPase homologues that are present in the Mycobacterium tuberculosis genome, real-time quantitative PCR expression analysis | Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
D86N | site-directed mutagenesis of gene impC | Mycobacterium tuberculosis |
additional information | construction of deletion mutants of genes impC and impA | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
inositol 1-phosphate + H2O | Mycobacterium tuberculosis | - |
myo-inositol + phosphate | - |
? | |
inositol 1-phosphate + H2O | Mycobacterium tuberculosis H37Rv, ATCC 25618 | - |
myo-inositol + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
genes impA or Rv1604, and impC or Rv3137 | - |
Mycobacterium tuberculosis H37Rv, ATCC 25618 | - |
genes impA or Rv1604, and impC or Rv3137 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inositol 1-phosphate + H2O | - |
Mycobacterium tuberculosis | myo-inositol + phosphate | - |
? | |
inositol 1-phosphate + H2O | - |
Mycobacterium tuberculosis H37Rv, ATCC 25618 | myo-inositol + phosphate | - |
? | |
myo-inositol 1-phosphate + H2O | - |
Mycobacterium tuberculosis | myo-inositol + phosphate | - |
? | |
myo-inositol 1-phosphate + H2O | - |
Mycobacterium tuberculosis H37Rv, ATCC 25618 | myo-inositol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IMPase | - |
Mycobacterium tuberculosis |
inositol monophosphate phosphatase | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mycobacterium tuberculosis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | Mycobacteria use inositol in phosphatidylinositol, for anchoring lipoarabinomannan, lipomannan, and phosphatidylinosotol mannosides in the cell envelope, and for the production of mycothiol, which maintains the redox balance of the cell. The protein encoded by gene impA is partly responsible for inositol synthesis, while the impC encoded protein is essential, overview | Mycobacterium tuberculosis |