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Literature summary for 3.1.3.25 extracted from

  • Morgan, A.J.; Wang, Y.K.; Roberts, M.F.; Miller, S.J.
    Chemistry and biology of deoxy-myo-inositol phosphates: stereospecificity of substrate interactions within an archaeal and a bacterial IMPase (2004), J. Am. Chem. Soc., 126, 15370-15371.
    View publication on PubMed
Search for more literature for 3.1.3.25

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
 Archaeoglobus fulgidus
Ca2+
-
 Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information reaction kinetics Escherichia coli
additional information
-
 additional information reaction kinetics Archaeoglobus fulgidus
0.047
-
 3-deoxy-D-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
0.051
-
 3,5-dideoxy-D-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
0.061
-
 L-myo-Inositol 1-phosphate pH 8.0, 37°C Escherichia coli
0.061
-
 D-myo-inositol 3-phosphate pH 8.0, 37°C Escherichia coli
0.068
-
 D-myo-Inositol 1-phosphate pH 8.0, 37°C Escherichia coli
0.1
-
 3,5-dideoxy-L-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
0.11
-
 D-myo-Inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
0.16
-
 3,5-dideoxy-D-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
0.2
-
 3-deoxy-L-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
0.23
-
 3-deoxy-D-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
1.7
-
 L-myo-Inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
1.7
-
 D-myo-inositol 3-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
2.3
-
 3-deoxy-L-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
4.9
-
 3,5-dideoxy-L-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Escherichia coli
Mg2+ dependent on Archaeoglobus fulgidus

Organism

Organism UniProt Comment Textmining
Archaeoglobus fulgidus
-
-
-
Escherichia coli
-
 gene suhB
-

Reaction

Reaction Comment Organism Reaction ID
myo-inositol phosphate + H2O = myo-inositol + phosphate catalytic mechanism and stereospecificity Escherichia coli
a
myo-inositol phosphate + H2O = myo-inositol + phosphate catalytic mechanism and stereospecificity Archaeoglobus fulgidus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,5-dideoxy-D-myo-inositol 1-phosphate + H2O
-
 Escherichia coli 3,5-dideoxy-D-myo-inositol + phosphate
-
 ?
3,5-dideoxy-D-myo-inositol 1-phosphate + H2O
-
 Archaeoglobus fulgidus 3,5-dideoxy-D-myo-inositol + phosphate
-
 ?
3,5-dideoxy-L-myo-inositol 1-phosphate + H2O
-
 Escherichia coli 3,5-dideoxy-L-myo-inositol + phosphate
-
 ?
3,5-dideoxy-L-myo-inositol 1-phosphate + H2O
-
 Archaeoglobus fulgidus 3,5-dideoxy-L-myo-inositol + phosphate
-
 ?
3-deoxy-D-myo-inositol 1-phosphate + H2O
-
 Escherichia coli 3-deoxy-D-myo-inositol + phosphate
-
 ?
3-deoxy-D-myo-inositol 1-phosphate + H2O
-
 Archaeoglobus fulgidus 3-deoxy-D-myo-inositol + phosphate
-
 ?
3-deoxy-L-myo-inositol 1-phosphate + H2O
-
 Escherichia coli 3-deoxy-L-myo-inositol + phosphate
-
 ?
3-deoxy-L-myo-inositol 1-phosphate + H2O
-
 Archaeoglobus fulgidus 3-deoxy-L-myo-inositol + phosphate
-
 ?
D-myo-inositol 1-phosphate + H2O
-
 Escherichia coli D-myo-inositol + phosphate
-
 ?
D-myo-inositol 1-phosphate + H2O substrate binding structure, interactions sites with the enzyme involving Tyr155 and Ala172 Archaeoglobus fulgidus D-myo-inositol + phosphate
-
 ?
D-myo-inositol 3-phosphate + H2O
-
 Escherichia coli D-myo-inositol + phosphate
-
 ?
D-myo-inositol 3-phosphate + H2O
-
 Archaeoglobus fulgidus D-myo-inositol + phosphate
-
 ?
L-myo-inositol 1-phosphate + H2O
-
 Escherichia coli L-myo-inositol + phosphate
-
 ?
L-myo-inositol 1-phosphate + H2O
-
 Archaeoglobus fulgidus L-myo-inositol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
IMPase
-
 Escherichia coli
IMPase
-
 Archaeoglobus fulgidus
IMPase/FBPase
-
 Archaeoglobus fulgidus
SuhB
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Escherichia coli
85
-
 assay at Archaeoglobus fulgidus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4
-
 L-myo-Inositol 1-phosphate pH 8.0, 37°C Escherichia coli
1.4
-
 D-myo-inositol 3-phosphate pH 8.0, 37°C Escherichia coli
2.5
-
 3,5-dideoxy-D-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.2
-
 3-deoxy-L-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.3
-
 D-myo-Inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.6
-
 L-myo-Inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.6
-
 D-myo-inositol 3-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
3.9
-
 3-deoxy-D-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus
4
-
 3,5-dideoxy-D-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
4.4
-
 D-myo-Inositol 1-phosphate pH 8.0, 37°C Escherichia coli
4.4
-
 3,5-dideoxy-L-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
4.4
-
 3-deoxy-D-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
5.6
-
 3-deoxy-L-myo-inositol 1-phosphate pH 8.0, 37°C Escherichia coli
5.8
-
 3,5-dideoxy-L-myo-inositol 1-phosphate pH 8.0, 85°C Archaeoglobus fulgidus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Escherichia coli
8
-
 assay at Archaeoglobus fulgidus