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Literature summary for 3.1.3.25 extracted from
- Stereochemistry at phosphorus of the reaction catalyzed by myo-inositol monophosphatase (2002), J. Med. Chem., 45, 1363-1373.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| phosphate | product inhibition, competitive | Bos taurus |  |
| phosphosulfate | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.11 | - |
inositol 3-phosphate | pH 9.0, 25°C | Bos taurus | |
| 0.21 | - |
inositol 1,3-thiophosphate | pH 9.0, 25°C | Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | two molecules bound per subunit | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29920 | - |
ESI-MS | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| myo-inositol 1-phosphate + H2O | Bos taurus | - |
myo-inositol + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| inositol 1,3-thiophosphate + H2O | - |
Bos taurus | ? | - |
? | |
| myo-inositol 1,3-thiophosphate + H2O | reaction 3times slower than reaction with inositol 1-phosphate | Bos taurus | ? | - |
? | |
| myo-inositol 1-phosphate + H2O | - |
Bos taurus | myo-inositol + phosphate | - |
? | |
| myo-inositol 1-phosphate + H2O | - |
Bos taurus | myo-inositol + phosphate | inversion of phosphate configuration | ? | |
| myo-inositol 3-phosphate + H2O | - |
Bos taurus | myo-inositol + phosphate | inversion of phosphate configuration | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | homodimer | Bos taurus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.19 | - |
inositol 1,3-thiophosphate | pH 9.0, 25°C | Bos taurus | |
| 0.48 | - |
inositol 3-phosphate | pH 9.0, 25°C | Bos taurus | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9 | no significant changes in activity | Bos taurus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.5 | - |
phosphosulfate | pH 6.5 and pH 9.0 | Bos taurus | |
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Release 2023.1 (January 2023)
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