Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
acid phosphatase | - |
Homo sapiens |
PAP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | in mice, intrathecal injection of human PAP reduces PIP2 levels in dorsal root ganglionss, inhibits thermosensation through TRPV1, and enduringly reduces thermal hyperalgesia and mechanical allodynia caused by inflammation, nerve injury, and pronociceptive receptor activation. This includes inhibitory effects on lysophosphatidic acid, purinergic (ATP), bradykinin, and protease-activated (thrombin) receptors | Homo sapiens |