Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli and Pichia pastoris | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
recombinant enzyme expressed in Escherichia coli and Pichia pastoris, the enzyme is in its oxidized, inactive state with both iron ions at the active site are Fe3+, X-ray diffraction structure determination and analysis at 2.2 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the repression loop involved in iron binding has an inhibitory function | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | the 22 iron ions bound at the active site are Fe2+ in the active enzyme state, and Fe3+ in the inactive state influencing the conformation of the repression loop, binding and structure overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P13686 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
PAP | - |
Homo sapiens |
purple acid phosphatase | - |
Homo sapiens |