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Literature summary for 3.1.3.2 extracted from
- Acid phosphatases (1971), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 4, 449-498.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| citrate | - |
Escherichia coli |  |
| citrate | slight activation | Homo sapiens | |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
General Stability
| General Stability | Organism |
|---|---|
| loses more than 90% of activity in 3 M urea at 25°C, pH 7.0 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-hydroyxy-5-nitrobenzyl bromide | - |
Homo sapiens | |
| arsenate | - |
Bos taurus | |
| arsenate | - |
Homo sapiens | |
| arsenate | - |
Saccharomyces mellis | |
| Borate | - |
Saccharomyces mellis | |
| Bromosuccinimide | - |
Homo sapiens | |
| Cu2+ | - |
Bos taurus | |
| Cu2+ | - |
Homo sapiens | |
| Cu2+ | - |
Rattus norvegicus | |
| cyanide | - |
Homo sapiens | |
| diisopropyl flurophosphate | - |
Homo sapiens | |
| F- | competitive | Bos taurus | |
| F- | - |
Drosophila melanogaster | |
| F- | - |
Escherichia coli | |
| F- | - |
Homo sapiens | |
| F- | - |
Lupinus luteus | |
| F- | competitive | Neurospora crassa | |
| F- | - |
Nicotiana tabacum | |
| F- | - |
Rattus norvegicus | |
| F- | - |
Staphylococcus aureus | |
| Fe2+ | - |
Bos taurus | |
| Fe2+ | - |
Homo sapiens | |
| Fe2+ | - |
Rattus norvegicus | |
| ICl | - |
Homo sapiens | |
| Mg2+ | - |
Bos taurus | |
| Mg2+ | - |
Homo sapiens | |
| molybdate | - |
Bos taurus | |
| molybdate | - |
Homo sapiens | |
| molybdate | - |
Lupinus luteus | |
| molybdate | - |
Neurospora crassa | |
| molybdate | - |
Nicotiana tabacum | |
| molybdate | - |
Rattus norvegicus | |
| molybdate | - |
Saccharomyces mellis | |
| molybdate | - |
Staphylococcus aureus | |
| oxalate | - |
Homo sapiens | |
| oxalate | - |
Neurospora crassa | |
| oxalate | - |
Rattus norvegicus | |
| p-mercuribenzoate | - |
Homo sapiens | |
| phosphate | - |
Bos taurus | |
| phosphate | - |
Drosophila melanogaster | |
| phosphate | - |
Homo sapiens | |
| phosphate | - |
Lupinus luteus | |
| phosphate | - |
Nicotiana tabacum | |
| phosphate | - |
Rattus norvegicus | |
| phosphate | - |
Saccharomyces mellis | |
| phosphate | - |
Staphylococcus aureus | |
| Tartrate | - |
Bos taurus | |
| Tartrate | - |
Drosophila melanogaster | |
| Tartrate | - |
Escherichia coli | |
| Tartrate | inhibition of enzyme from prostate, no inhibition of enzyme from erythrocytes | Homo sapiens | |
| Tartrate | D-(+)-tartrate | Neurospora crassa | |
| Tartrate | D-(+)-tartrate | Rattus norvegicus | |
| taurocholate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.75 | - |
p-nitrophenyl phosphate | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
| lysosome | - |
Rattus norvegicus | 5764 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 16590 | - |
equilibrium sedimentation | Bos taurus |
| 58000 | - |
gel filtration | Staphylococcus aureus |
| 89100 | - |
sucrose density gradient centrifugation | Homo sapiens |
| 100000 | - |
- |
Homo sapiens |
| 100000 | - |
sucrose density gradient centrifugation, gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Chaos carolinense | - |
- |
- |
| Drosophila melanogaster | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Lupinus luteus | - |
- |
- |
| Mus musculus | - |
- |
- |
| Neurospora crassa | - |
- |
- |
| Nicotiana tabacum | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Saccharomyces mellis | - |
- |
- |
| Staphylococcus aureus | - |
PS 55 | - |
| Staphylococcus aureus PS 55 | - |
PS 55 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Staphylococcus aureus |
- |
Rattus norvegicus |
- |
Neurospora crassa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| leaf | - |
Nicotiana tabacum | - |
| liver | - |
Staphylococcus aureus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | Kupffer cells | Mus musculus | - |
| prostate gland | - |
Homo sapiens | - |
| prostate gland | - |
Rattus norvegicus | - |
| seedling | - |
Lupinus luteus | - |
| semen | - |
Homo sapiens | - |
| serum | - |
Rattus norvegicus | - |
| serum | - |
Bos taurus | - |
| spleen | - |
Homo sapiens | - |
| spleen | - |
Rattus norvegicus | - |
| spleen | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
| additional information | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -25°C, pH 6.0, stable for years | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2',3'-AMP + H2O | - |
Bos taurus | ? | - |
? | |
| 2-glycerophosphate + H2O | - |
Homo sapiens | glycerol + phosphate | - |
? | |
| 2-glycerophosphate + H2O | - |
Rattus norvegicus | glycerol + phosphate | - |
? | |
| 2-glycerophosphate + H2O | - |
Bos taurus | glycerol + phosphate | - |
? | |
| 2-glycerophosphate + H2O | - |
Neurospora crassa | glycerol + phosphate | - |
? | |
| 5'-AMP + H2O | - |
Bos taurus | adenosine + phosphate | - |
? | |
| 5'-UMP + H2O | 5% of the activity with p-nitrophenyl phosphate | Bos taurus | uridine + phosphate | - |
? | |
| alpha-glycerophosphate + H2O | - |
Staphylococcus aureus | glycerol + phosphate | - |
? | |
| alpha-glycerophosphate + H2O | - |
Rattus norvegicus | glycerol + phosphate | - |
? | |
| alpha-glycerophosphate + H2O | - |
Bos taurus | glycerol + phosphate | - |
? | |
| alpha-glycerophosphate + H2O | - |
Neurospora crassa | glycerol + phosphate | - |
? | |
| alpha-glycerophosphate + H2O | - |
Staphylococcus aureus PS 55 | glycerol + phosphate | - |
? | |
| FMN + H2O | - |
Rattus norvegicus | ? | - |
? | |
| FMN + H2O | 68% of the activity with p-nitrophenyl phosphate | Bos taurus | ? | - |
? | |
| galactose 6-phosphate + H2O | 39% of the activity with p-nitrophenyl phosphate | Bos taurus | galactose + phosphate | - |
? | |
| glucose 1-phosphate + H2O | - |
Escherichia coli | glucose + phosphate | - |
? | |
| glucose 1-phosphate + H2O | - |
Homo sapiens | glucose + phosphate | - |
? | |
| glucose 1-phosphate + H2O | - |
Bos taurus | glucose + phosphate | - |
? | |
| glucose 1-phosphate + H2O | - |
Lupinus luteus | glucose + phosphate | - |
? | |
| glucose 1-phosphate + H2O | - |
Nicotiana tabacum | glucose + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Staphylococcus aureus | p-nitrophenol + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Escherichia coli | p-nitrophenol + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Homo sapiens | p-nitrophenol + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Rattus norvegicus | p-nitrophenol + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Bos taurus | p-nitrophenol + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Lupinus luteus | p-nitrophenol + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Nicotiana tabacum | p-nitrophenol + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Staphylococcus aureus PS 55 | p-nitrophenol + phosphate | - |
? | |
| phenyl phosphate + H2O | - |
Homo sapiens | phenol + phosphate | - |
? | |
| phenyl phosphate + H2O | - |
Rattus norvegicus | phenol + phosphate | - |
? | |
| phenyl phosphate + H2O | - |
Bos taurus | phenol + phosphate | - |
? | |
| phenyl phosphate + H2O | - |
Lupinus luteus | phenol + phosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
- |
Homo sapiens |
| 5.5 | - |
- |
Bos taurus |
| 5.6 | - |
hydrolysis of 2-glycerophosphate | Neurospora crassa |
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