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Literature summary for 3.1.3.16 extracted from

  • Okamura, H.; Yoshida, K.; Yang, D.; Haneji, T.
    Protein phosphatase 2A Calpha regulates osteoblast differentiation and the expressions of bone sialoprotein and osteocalcin via osterix transcription factor (2013), J. Cell. Physiol., 228, 1031-1037.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoprotein + H2O Mus musculus
-
protein + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MC3T3-E1 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoprotein + H2O
-
Mus musculus protein + phosphate
-
?

Synonyms

Synonyms Comment Organism
PP2A Calpha
-
Mus musculus
protein phosphatase 2A Calpha
-
Mus musculus

General Information

General Information Comment Organism
malfunction a decrease in alpha-isoform of PP2A catalytic subunit accelerates osteoblast differentiation through the expression of bone-related genes Mus musculus
physiological function overexpression of subunit PP2A Calpha reduces alkaline phosphatase activity. Osteoblast differentiation and mineralization are decreased in subunit PP2A Calpha-overexpressing cells, with reduction of bone-related genes including osterix, bone sialoprotein, and osteocalcin Mus musculus