Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoprotein + H2O | Mus musculus | - |
protein + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MC3T3-E1 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoprotein + H2O | - |
Mus musculus | protein + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PP2A Calpha | - |
Mus musculus |
protein phosphatase 2A Calpha | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | a decrease in alpha-isoform of PP2A catalytic subunit accelerates osteoblast differentiation through the expression of bone-related genes | Mus musculus |
physiological function | overexpression of subunit PP2A Calpha reduces alkaline phosphatase activity. Osteoblast differentiation and mineralization are decreased in subunit PP2A Calpha-overexpressing cells, with reduction of bone-related genes including osterix, bone sialoprotein, and osteocalcin | Mus musculus |