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Literature summary for 3.1.3.16 extracted from

  • Sents, W.; Ivanova, E.; Lambrecht, C.; Haesen, D.; Janssens, V.
    The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity (2013), FEBS J., 280, 644-661.
    View publication on PubMed
Search for more literature for 3.1.3.16

Inhibitors

Inhibitors Comment Organism Structure
microcystin
-
 Homo sapiens
okadaic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoprotein + H2O Homo sapiens
-
 protein + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
methylation
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoprotein + H2O
-
 Homo sapiens protein + phosphate
-
 ?
phosphorylated Mid1 + H2O
-
 Homo sapiens Mid1 + phosphate
-
 ?
phosphorylated mitogen-activated protein kinase kinase 3 + H2O
-
 Homo sapiens mitogen-activated protein kinase kinase 3 + phosphate
-
 ?

Subunits

Subunits Comment Organism
heterotrimer the majority of PP2A complexes within a cell are heterotrimers, consisting of a catalytic C subunit, a structural A subunit, and one regulatory B-type subunit Homo sapiens

Synonyms

Synonyms Comment Organism
PP2A
-
 Homo sapiens
protein phosphatase 2A
-
 Homo sapiens
Ser/Thr protein phosphatase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens highly expressed in several human cancers (in 87.5% of primary hepatocellular carcinomas, 84% of primary lung cancers, and 81.8% of primary breast cancers) up