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Literature summary for 3.1.3.16 extracted from

  • Juhasz, T.; Matta, C.; Veress, G.; Nagy, G.; Szijgyarto, Z.; Molnar, Z.; Fodor, J.; Zakany, R.; Gergely, P.
    Inhibition of calcineurin by cyclosporine A exerts multiple effects on human melanoma cell lines HT168 and WM35 (2009), Int. J. Oncol., 34, 995-1003.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin calcineurin is dependent on Ca2+/calmodulin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cyclosporin A a specific pharmacological inhibitor of calcineurin. Cyclosporin A modulates cell shape and actin organization of melanoma cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ calcineurin is dependent on Ca2+/calmodulin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-168 cell selected from A2058 cell line Homo sapiens
-
melanoma cell
-
Homo sapiens
-
WM-35 cell established from a primary cutaneous melanoma of radial growth phase Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated protein phosphatase inhibitor-1 + H2O
-
Homo sapiens protein phosphatase inhibitor-1 + phosphate
-
?

Synonyms

Synonyms Comment Organism
calcineurin
-
Homo sapiens
PP2B
-
Homo sapiens

General Information

General Information Comment Organism
malfunction partly malignancy-dependent role of calcineurin in melanoma cell lines, overview. Calcineurin-inhibiting compounds are applied for local treatment of psoriasis or atopic dermatitis Homo sapiens