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Literature summary for 3.1.3.16 extracted from

  • Nicolaou, P.; Rodriguez, P.; Ren, X.; Zhou, X.; Qian, J.; Sadayappan, S.; Mitton, B.; Pathak, A.; Robbins, J.; Hajjar, R.J.; Jones, K.; Kranias, E.G.
    Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury (2009), Circ. Res., 104, 1012-1020.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
protein phosphatase-1 inhibitor-1 the inhibitor-1 contains an RVXF motif sequence, which facilitates its interaction with PP1. On stimulation of the beta-adrenergic axis, protein kinase A phosphorylates Thr35 in inhibitor-1, resulting in PP1 inhibition and amplification of the contractile response Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Mus musculus
-
muscle
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
PPI1
-
Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme is involved in regulation of diverse enzyme functions via de-/activation of phosphoproteins through dephosphorylation, in the same way its inhibitor protein phosphatase-1 inhibitor-1, phosphoproteomic analysis, overview Mus musculus