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Literature summary for 3.1.3.16 extracted from
- Infusion of FK506, a specific inhibitor of calcineurin, induces potent tau hyperphosphorylation in mouse brain (2008), Brain Res. Bull., 76, 464-468.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | calcineurin is dependent on Ca2+/calmodulin | Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyclosporin A | a specific calcineurin inhibitor, time course of inhibition in vivo, overview | Mus musculus | |
| FK506 | a specific calcineurin inhibitor, time course of inhibition in vivo, overview | Mus musculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | calcineurin is dependent on Ca2+/calmodulin | Mus musculus | |
| Mg2+ | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | calcineurin is a Ca2+/calmodulin-dependent protein phosphatase | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
male BALB/c mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | high expression level of calcineurin | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000245 | - |
wild-type brain | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | calcineurin is a Ca2+/calmodulin-dependent protein phosphatase | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calcineurin | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | calcineurin inhibition by FK506 significantly enhances the phosphorylation of protein tau at Ser262, Ser198, Ser199, and/or Ser202 and Ser396, and/or Ser404, overview | Mus musculus |
| physiological function | calcineurin plays an important role in brain function and in regulation of tau phosphorylation | Mus musculus |
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