Any feedback?
Literature summary for 3.1.3.16 extracted from
- A bienzyme electrochemical probe for flow injection analysis of okadaic acid based on protein phosphatase-2A inhibition: an optimization study (2009), Anal. Biochem., 385, 50-56.
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | assembly of a biosensor system involving protein phosphatase-2A and glycogen phosphorylase a activities, method optimization, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| okadaic acid | a polyether derivative of a C38 fatty acid produced by toxigenic dinoflagellates, Dynophysis and Prorocentrum, strong inhibition by okadaic acid and derivatives | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphorylated glycogen phosphorylase a + H2O | Homo sapiens | inactivation of the substrate enzyme, overview | glycogen phosphorylase a + phosphate | - |
? | |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| Ethanol | inhibits the enzyme at 2-5% v/v, no inactivation at 1% ethanol after 10 min | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | as commercial preparation | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphorylated glycogen phosphorylase a + H2O | - |
Homo sapiens | glycogen phosphorylase a + phosphate | - |
? | |
| phosphorylated glycogen phosphorylase a + H2O | inactivation of the substrate enzyme, overview | Homo sapiens | glycogen phosphorylase a + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PP2A | - |
Homo sapiens |
| protein phosphatase type 2A | - |
Homo sapiens |
| protein phosphatase-2A | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
