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Literature summary for 3.1.3.16 extracted from

  • Traweger, A.; Wiggin, G.; Taylor, L.; Tate, S.A.; Metalnikov, P.; Pawson, T.
    Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3 (2008), Proc. Natl. Acad. Sci. USA, 105, 10402-10407.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
PP1alpha N-terminally tagged with a monomeric variant of red fluorescent protein is expressed in MDCKII cells Mus musculus

Protein Variants

Protein Variants Comment Organism
H248K catalytically inactive mutant of PP1alpha Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
I-2 protein PP1-specific inhibitor Mus musculus
additional information Par-3 does not inhibit the enzymatic activity of PP1alpha Mus musculus
okadaic acid
-
Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
PP1alpha, tandem mass spectrometry Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo mouse E13 embryonic tissue Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
14-3-3epsilon phosphoprotein + H2O
-
Mus musculus 14-3-3epsilon protein + phosphate
-
?
KRpTIRR + H2O
-
Mus musculus KRTIRR + phosphate
-
?
phosphorylated angiomotin + H2O
-
Mus musculus angiomotin + phosphate
-
?
phosphorylated atypical protein kinase C + H2O
-
Mus musculus atypical protein kinase C + phosphate
-
?
phosphorylated DNA-protease K + H2O
-
Mus musculus DNA-protease K + phosphate
-
?
phosphorylated Par-3 + H2O predominantly the alpha-isoform of PP1 binds phosphorylated Par-3 and specifically dephosphorylates at Ser-144 and Ser-824 Mus musculus Par-3 + phosphate
-
?
phosphorylated Par-6 + H2O
-
Mus musculus Par-6 + phosphate
-
?
SSpSLESLQTAVAEVTLNGNIPFHRPR + H2O
-
Mus musculus SSSLESLQTAVAEVTLNGNIPFHRPR + phosphate
-
?

Synonyms

Synonyms Comment Organism
PP1
-
Mus musculus
PP1alpha isoform Mus musculus
protein phosphatase 1
-
Mus musculus