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Literature summary for 3.1.3.16 extracted from

  • Jones, C.; Anderson, S.; Singha, U.K.; Chaudhuri, M.
    Protein phosphatase 5 is required for Hsp90 function during proteotoxic stresses in Trypanosoma brucei (2008), Parasitol. Res., 102, 835-844.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
microcystin inhibits by binding tightly to the phosphatase catalytic domain of PP5 Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol under normal growth conditions, PP5 is primarily localized in the cytosol Trypanosoma brucei 5829
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nucleus with increase in growth temperature (up to 40°C) and geldanamycin treatment, PP5 translocates to the nucleus Trypanosoma brucei 5634
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Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
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Purification (Commentary)

Purification (Comment) Organism
microcystin-Sepharose bead chromatography Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated Hsp90 + H2O PP5 positively regulates the function of Hsp90 to maintain cellular homeostasis during proteotoxic stresses Trypanosoma brucei Hsp90 + phosphate
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Synonyms

Synonyms Comment Organism
PP5
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Trypanosoma brucei
protein phosphatase 5
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Trypanosoma brucei