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Literature summary for 3.1.3.16 extracted from

  • Yoo, S.J.; Jimenez, R.H.; Sanders, J.A.; Boylan, J.M.; Brautigan, D.L.; Gruppuso, P.A.
    The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells (2008), J. Cell. Biochem., 105, 290-300.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
L309Q the mutant enzyme cannot be methylated Mus musculus
L309Q the mutant enzyme cannot be methylated Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
alpha 4 protein rapamycin has no effect on PP2A-C association with the inhibitor alpha 4 protein Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
wild type PP2A-C, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification methylation at Leu309 Mus musculus
side-chain modification methylation at Leu309 Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
Mono Q column chromatography Mus musculus
Mono Q column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
1682-A cell
-
Rattus norvegicus
-
AML-12 cell
-
Mus musculus
-
GN5 cell
-
Rattus norvegicus
-
GP6 cell
-
Rattus norvegicus
-
liver fetal and adult liver Rattus norvegicus
-
THC-252 cell
-
Rattus norvegicus
-
THC-H5D cell
-
Rattus norvegicus
-
WB-311 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
KRpTIRR + H2O
-
Mus musculus KRTIRR + phosphate
-
?
KRpTIRR + H2O
-
Rattus norvegicus KRTIRR + phosphate
-
?
myelin basic phosphoprotein + H2O
-
Mus musculus myelin basic protein + phosphate
-
?
myelin basic phosphoprotein + H2O
-
Rattus norvegicus myelin basic protein + phosphate
-
?

Synonyms

Synonyms Comment Organism
alpha4/PP2A-C alpha4 binds to PP2A-C independent of the A and B subunits Mus musculus
alpha4/PP2A-C alpha4 binds to PP2A-C independent of the A and B subunits Rattus norvegicus
PP2A
-
Mus musculus
PP2A
-
Rattus norvegicus
PP2A-C PP2A catalytic subunit Mus musculus
PP2A-C PP2A catalytic subunit Rattus norvegicus
protein phosphatase 2A
-
Mus musculus
protein phosphatase 2A
-
Rattus norvegicus