Literature summary for 3.1.3.16 extracted from

Sahin, F.; Celik, H.A.; Aydin, H.H.; Oktem, G.; Omay, S.B.; Saydam, G.
The interaction between taxoids and serine/threonine protein phosphatase activities during taxan-induced apoptosis of HL 60 leukemic cells (2008), Hematology, 13, 215-223.

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Activating Compound

Activating Compound	Comment	Organism	Structure
docetaxel	docetaxel induces increase in activity of protein phosphatase 2 subgroups	Homo sapiens
paclitaxel	paclitaxel induces the increase in the activity of protein phosphatase 1	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
docetaxel	docetaxel induces the decrease in the activity of protein phosphatase 1	Homo sapiens
paclitaxel	paclitaxel induces decrease in activity of protein phosphatase 2 subgroups	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphoprotein + H2O	-	Homo sapiens	protein + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PP1	-	Homo sapiens
PP2	-	Homo sapiens
protein phosphatase 1	-	Homo sapiens
protein phosphatase 2	-	Homo sapiens

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Release 2023.1 (January 2023)