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Literature summary for 3.1.3.16 extracted from
- Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection (2008), Endocrinology, 149, 5235-5243.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| estrogen | estrogen maintains the function of isozymes PP1, PP2A, and calcineurin | Rattus norvegicus |  |
| estrogen | estrogen maintains the function of PP1, PP2A, and calcineurin | Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyclosporin A | specific inhibitor of calcineurin | Homo sapiens | |
| cyclosporin A | specific inhibitor of calcineurin | Rattus norvegicus | |
| endothall | specific inhibitor of isozyme PP2A | Homo sapiens | |
| endothall | specific inhibitor of isozyme PP2A | Rattus norvegicus | |
| glutamate | inhibitor of isozyme PP2A | Homo sapiens | |
| glutamate | inhibitor of isozyme PP2A | Rattus norvegicus | |
| additional information | protein phosphatase inhibitor II and cyclosporin A have no inhibitory effect on isozyme PP2A | Homo sapiens | |
| additional information | protein phosphatase inhibitor II and cyclosporin A have no inhibitory effect on isozyme PP2A | Rattus norvegicus | |
| okadaic acid | inhibitor of isozyme PP2A | Homo sapiens | |
| okadaic acid | inhibitor of isozyme PP2A | Rattus norvegicus | |
| protein phosphatase inhibitor II | specific inhibitor of isozyme PP1 | Homo sapiens | |
| protein phosphatase inhibitor II | specific inhibitor of isozyme PP1 | Rattus norvegicus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32000 | - |
isozyme PP1, SDS-PAGE | Homo sapiens |
| 32000 | - |
isozyme PP2A, SDS-PAGE | Homo sapiens |
| 60000 | - |
isozyme PP2B, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| C6 glioma cell | - |
Rattus norvegicus | - |
| cerebral cortical neuron | - |
Rattus norvegicus | - |
| glioma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phospho-threonylpeptide + H2O | - |
Homo sapiens | threonylpeptide + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calcineurin | - |
Homo sapiens |
| calcineurin | - |
Rattus norvegicus |
| PP1 | - |
Homo sapiens |
| PP1 | - |
Rattus norvegicus |
| PP2A | - |
Homo sapiens |
| PP2A | - |
Rattus norvegicus |
| PP2B | - |
Homo sapiens |
| PP2B | - |
Rattus norvegicus |
| protein phosphatase 1 | - |
Homo sapiens |
| protein phosphatase 1 | - |
Rattus norvegicus |
| protein phosphatase 2A | - |
Homo sapiens |
| protein phosphatase 2A | - |
Rattus norvegicus |
| protein phosphatase 2B | - |
Homo sapiens |
| protein phosphatase 2B | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | - |
Homo sapiens | |
| Calmodulin | - |
Rattus norvegicus | |
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