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Literature summary for 3.1.3.16 extracted from

  • Golden, T.; Swingle, M.; Honkanen, R.E.
    The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer (2008), Cancer Metastasis Rev., 27, 169-178.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information an increase in PP5 protein levels is observed following prolonged hypoxia or treatment with reagents that induce oxidative stress Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y451A okadaic acid insensitive mutant of PP5 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
calyculin A
-
Homo sapiens
cantharidin
-
Homo sapiens
nodularin
-
Homo sapiens
okadaic acid
-
Homo sapiens
tautomycin
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PP5 binds the A-subunit of the PP2A holoenzyme, which functions to tether the catalytic (PP2Ac) and substrate targeting B-subunits of PP2A ?
-
?
additional information Homo sapiens PP5 is a potentially important regulator of both hormone- and stress-induced signaling networks that enable a cell to respond appropriately to genomic stress ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P53041
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PP5 binds the A-subunit of the PP2A holoenzyme, which functions to tether the catalytic (PP2Ac) and substrate targeting B-subunits of PP2A Homo sapiens ?
-
?
additional information PP5 is a potentially important regulator of both hormone- and stress-induced signaling networks that enable a cell to respond appropriately to genomic stress Homo sapiens ?
-
?
phosphorylated apoptosis signal-regulating kinase 1 + H2O apoptosis signal-regulating kinase 1 is transiently activated by autophosphorylation at Thr845 Homo sapiens apoptosis signal-regulating kinase 1 + phosphate
-
?
phosphorylated ataxia telangiectasia mutated kinase + H2O
-
Homo sapiens ataxia telangiectasia mutated kinase + phosphate
-
?
phosphorylated ATM and Rad 3 related kinase + H2O
-
Homo sapiens ATM and Rad 3 related kinase + phosphate
-
?
phosphorylated glucocorticoid receptor-heat shock protein 90 + H2O
-
Homo sapiens glucocorticoid receptor-heat shock protein 90 + phosphate
-
?
phosphorylated Ser/Thr protein kinase + H2O
-
Homo sapiens DNA-dependent Ser/Thr protein kinase + phosphate
-
?
Raf proto-oncogene serine/threonine protein kinase + H2O PP5 plays a role in the inactivation of Raf proto-oncogene serine/threonine protein kinase, PP5/Raf proto-oncogene serine/threonine protein kinase association occurs in response to growth factor stimulation and results in the selective dephosphorylation of Ser338, removing phosphate from this critical site that helps to maintain Raf proto-oncogene serine/threonine protein kinase activation Homo sapiens dephosphorylated Raf proto-oncogene serine/threonine protein kinase + phosphate
-
?

Synonyms

Synonyms Comment Organism
PP5 the catalytic domain of PP5 was originally designated as PP3 Homo sapiens
serine/threonine protein phosphatase type 5
-
Homo sapiens