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Literature summary for 3.1.3.16 extracted from

  • Wang, K.; Song, Y.; Chen, D.B.; Zheng, J.
    Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial cells (2008), Biol. Reprod., 79, 704-710.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.16

Cloned(Commentary)

Cloned (Comment) Organism
expressed in fetoplacental artery endothelial cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
FK506 selective PPP3 inhibitor Homo sapiens
additional information 20 and 40 nM PPP3CA siRNA decreases PPP3CA protein levels by about 97% but not PPP2CA potein expression, knockdown of PPP3CA protein expression enhances vascular endothelial growth factor-beta, but not fibroblast growth factor 2-stimulated cell proliferation, knockdown of PPP3CA protein expression does not significantly affect vascular endothelial growth factor-induced mitogen-activated protein kinase 3/1 and phosphoinositide 3-kinase/v-akt murine thymoma viral oncogen homolog 1 phosphorylation, while attenuates fibroblast growth factor 2-induced mitogen-activated protein kinase 3/1 and phosphoinositide 3-kinase/v-akt murine thymoma viral oncogen homolog 1 phosphorylation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoprotein + H2O
-
 Homo sapiens protein + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PPP2CA protein phosphatase 2 catalytic subunit alpha Homo sapiens
PPP3
-
 Homo sapiens
PPP3CA protein phosphatase 3 catalytic subunit alpha Homo sapiens
protein phosphatase 2
-
 Homo sapiens
protein phosphatase 3
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
Calmodulin
-
 Homo sapiens