Literature summary for 3.1.3.16 extracted from

Chen, Y.; Xu, Y.; Bao, Q.; Xing, Y.; Li, Z.; Lin, Z.; Stock, J.B.; Jeffrey, P.D.; Shi, Y.
Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40 (2007), Nat. Struct. Mol. Biol., 14, 527-534.

Search for more literature for 3.1.3.16

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in insect cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapour diffusion method with 0.2 M MgCl2, 4.5% PEG 10000 (w/v) and 0.1 M HEPES (pH 7.5)	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
small t antigen	small t antigen of DNA tumor virus SV40 inhibits the phosphatase activity of the PP2A core enzyme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
glutathione affinity column chromatography, Source 15Q column chromatography, and Superdex 200 gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphorylated phosphorylase a + H2O	-	Homo sapiens	phosphorylase a + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PP2A	-	Homo sapiens
protein phosphatase 2A	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0002	-	using phosphorylase a as a substrate	Homo sapiens	small t antigen

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Release 2023.1 (January 2023)