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Literature summary for 3.1.3.16 extracted from

  • Kray, A.E.; Carter, R.S.; Pennington, K.N.; Gomez, R.J.; Sanders, L.E.; Llanes, J.M.; Khan, W.N.; Ballard, D.W.; Wadzinski, B.E.
    Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A (2005), J. Biol. Chem., 280, 35974-35982.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
fostriecin
-
Mus musculus
okadaic acid
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated IkappaB kinase + H2O Mus musculus PP2A positively regulates multicomponent Ikappa kinase signaling, eventhough it inhibits its activity by dephosphorylation, positive regulation requires PP2A-IKK complex formation, suppression of the complex formation attenuates IKK T loop phosphorylation and activation, PP2A inhibition attenuates TNFalpha-induced IKK degradation, overview IkappaB kinase + phosphate
-
?
phosphorylated IkappaB kinase + H2O Mus musculus C57BL6 PP2A positively regulates multicomponent Ikappa kinase signaling, eventhough it inhibits its activity by dephosphorylation, positive regulation requires PP2A-IKK complex formation, suppression of the complex formation attenuates IKK T loop phosphorylation and activation, PP2A inhibition attenuates TNFalpha-induced IKK degradation, overview IkappaB kinase + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
C57Bl6 mice
-
Mus musculus C57BL6
-
C57Bl6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte primary Mus musculus
-
spleen
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated IkappaB kinase + H2O PP2A positively regulates multicomponent Ikappa kinase signaling, eventhough it inhibits its activity by dephosphorylation, positive regulation requires PP2A-IKK complex formation, suppression of the complex formation attenuates IKK T loop phosphorylation and activation, PP2A inhibition attenuates TNFalpha-induced IKK degradation, overview Mus musculus IkappaB kinase + phosphate
-
?
phosphorylated IkappaB kinase + H2O formation of PP2A-IKK complexes, determination of interaction sites Mus musculus IkappaB kinase + phosphate
-
?
phosphorylated IkappaB kinase + H2O PP2A positively regulates multicomponent Ikappa kinase signaling, eventhough it inhibits its activity by dephosphorylation, positive regulation requires PP2A-IKK complex formation, suppression of the complex formation attenuates IKK T loop phosphorylation and activation, PP2A inhibition attenuates TNFalpha-induced IKK degradation, overview Mus musculus C57BL6 IkappaB kinase + phosphate
-
?
phosphorylated IkappaB kinase + H2O formation of PP2A-IKK complexes, determination of interaction sites Mus musculus C57BL6 IkappaB kinase + phosphate
-
?

Synonyms

Synonyms Comment Organism
PP2A
-
Mus musculus
protein serine/threonine phosphatase 2A
-
Mus musculus