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Literature summary for 3.1.3.16 extracted from

  • Hatori, H.; Zenkoh, T.; Kobayashi, M.; Ohtsu, Y.; Shigematsu, N.; Setoi, H.; Hino, M.; Handa, H.
    FR225659-binding proteins: identification as serine/threonine protein phosphatase PP1 and PP2A using high-performance affinity beads (2004), J. Antibiot., 57, 456-461.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
FR225659 synthesizes by Helicomyces sp. strain 19353, inhibits PP1 and PP2A, inhibition of gluconeogenese in vivo in hepatocytes Rattus norvegicus
FR253761 synthetic derivative of FR225659, inhibits PP1 and PP2A, inhibition of gluconeogenese in vivo in hepatocytes Rattus norvegicus
FR259383 synthetic derivative of FR225659, inhibits PP1 and PP2A, inhibition of gluconeogenese in vivo in hepatocytes Rattus norvegicus
okadaic acid
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
x * 36000, catalytic subunit of PP1, SDS-PAGE, x * 37000, catalytic subunit of PP2A, SDS-PAGE, x * 60000, regulatory subunit of PP2A, SDS-PAGE Rattus norvegicus
37000
-
x * 36000, catalytic subunit of PP1, SDS-PAGE, x * 37000, catalytic subunit of PP2A, SDS-PAGE, x * 60000, regulatory subunit of PP2A, SDS-PAGE Rattus norvegicus
60000
-
x * 36000, catalytic subunit of PP1, SDS-PAGE, x * 37000, catalytic subunit of PP2A, SDS-PAGE, x * 60000, regulatory subunit of PP2A, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
separation of isozyme subunits by latex bead-immobilized-inhibitor affinity chromatography using FR225659, FR23761, and FR259383 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated glycogen phosphorylase + H2O
-
Rattus norvegicus glycogen phosphorylase + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 36000, catalytic subunit of PP1, SDS-PAGE, x * 37000, catalytic subunit of PP2A, SDS-PAGE, x * 60000, regulatory subunit of PP2A, SDS-PAGE Rattus norvegicus
More the enzyme is located in a multimeric phosphorylation complex in giant neurons Rattus norvegicus

Synonyms

Synonyms Comment Organism
PP1
-
Rattus norvegicus
PP2A
-
Rattus norvegicus
serine/threonine protein phosphatase type1
-
Rattus norvegicus
serine/threonine protein phosphatase type2A
-
Rattus norvegicus