Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FR225659 | synthesizes by Helicomyces sp. strain 19353, inhibits PP1 and PP2A, inhibition of gluconeogenese in vivo in hepatocytes | Rattus norvegicus | |
FR253761 | synthetic derivative of FR225659, inhibits PP1 and PP2A, inhibition of gluconeogenese in vivo in hepatocytes | Rattus norvegicus | |
FR259383 | synthetic derivative of FR225659, inhibits PP1 and PP2A, inhibition of gluconeogenese in vivo in hepatocytes | Rattus norvegicus | |
okadaic acid | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
36000 | - |
x * 36000, catalytic subunit of PP1, SDS-PAGE, x * 37000, catalytic subunit of PP2A, SDS-PAGE, x * 60000, regulatory subunit of PP2A, SDS-PAGE | Rattus norvegicus |
37000 | - |
x * 36000, catalytic subunit of PP1, SDS-PAGE, x * 37000, catalytic subunit of PP2A, SDS-PAGE, x * 60000, regulatory subunit of PP2A, SDS-PAGE | Rattus norvegicus |
60000 | - |
x * 36000, catalytic subunit of PP1, SDS-PAGE, x * 37000, catalytic subunit of PP2A, SDS-PAGE, x * 60000, regulatory subunit of PP2A, SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
separation of isozyme subunits by latex bead-immobilized-inhibitor affinity chromatography using FR225659, FR23761, and FR259383 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated glycogen phosphorylase + H2O | - |
Rattus norvegicus | glycogen phosphorylase + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 36000, catalytic subunit of PP1, SDS-PAGE, x * 37000, catalytic subunit of PP2A, SDS-PAGE, x * 60000, regulatory subunit of PP2A, SDS-PAGE | Rattus norvegicus |
More | the enzyme is located in a multimeric phosphorylation complex in giant neurons | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
PP1 | - |
Rattus norvegicus |
PP2A | - |
Rattus norvegicus |
serine/threonine protein phosphatase type1 | - |
Rattus norvegicus |
serine/threonine protein phosphatase type2A | - |
Rattus norvegicus |