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Literature summary for 3.1.3.16 extracted from
- Calcineurin: roles of the Ca2+/calmodulin-dependent protein phosphatase in diverse eukaryotes (2004), Topics in Current Genetics (Arino, J. , Alexander, D. R. Eds. ) Springer, 5, 73-90.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | - |
Schizosaccharomyces pombe |  |
| Calmodulin | - |
Candida albicans | |
| Calmodulin | - |
Cryptococcus neoformans | |
| Rcn1 | enhances calcineurin signaling when expressed at low levels | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Rcn1 | inhibits calcineurin signaling when expressed at high levels | Saccharomyces cerevisiae |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Saccharomyces cerevisiae | |
| Ca2+ | - |
Schizosaccharomyces pombe | |
| Ca2+ | - |
Candida albicans | |
| Ca2+ | - |
Cryptococcus neoformans | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphorylated Cbp1 + H2o | Cryptococcus neoformans | - |
Cbp1 + phosphate | - |
? | |
| phosphorylated protein kinase Hs11 + H2O | Saccharomyces cerevisiae | contributes to its delocalization and destruction | protein kinase Hs11 + phosphate | - |
? | |
| phosphorylated Prz1 + H2o | Schizosaccharomyces pombe | induction of calcineurin itself and the Pmc1 CXa2+ ATPase | Prz1 + phosphate | - |
? | |
| phosphorylated Tcn1/Crz1 + H2O | Saccharomyces cerevisiae | promotes its translocation into the nucleus and exposure of a transcription activation domain | Tcn1/Crz1 + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida albicans | - |
- |
- |
| Cryptococcus neoformans | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Schizosaccharomyces pombe | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphorylated Cbp1 + H2o | - |
Cryptococcus neoformans | Cbp1 + phosphate | - |
? | |
| phosphorylated protein kinase Hs11 + H2O | contributes to its delocalization and destruction | Saccharomyces cerevisiae | protein kinase Hs11 + phosphate | - |
? | |
| phosphorylated protein kinase Hs11 + H2O | at high Ca2+ concentrations | Saccharomyces cerevisiae | protein kinase Hs11 + phosphate | - |
? | |
| phosphorylated Prz1 + H2o | - |
Schizosaccharomyces pombe | Prz1 + phosphate | - |
? | |
| phosphorylated Prz1 + H2o | induction of calcineurin itself and the Pmc1 CXa2+ ATPase | Schizosaccharomyces pombe | Prz1 + phosphate | - |
? | |
| phosphorylated Tcn1/Crz1 + H2O | - |
Saccharomyces cerevisiae | Tcn1/Crz1 + phosphate | - |
? | |
| phosphorylated Tcn1/Crz1 + H2O | promotes its translocation into the nucleus and exposure of a transcription activation domain | Saccharomyces cerevisiae | Tcn1/Crz1 + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| calcineurin | - |
Saccharomyces cerevisiae |
| calcineurin | - |
Schizosaccharomyces pombe |
| calcineurin | - |
Candida albicans |
| calcineurin | - |
Cryptococcus neoformans |
| PP2B | - |
Saccharomyces cerevisiae |
| PP2B | - |
Schizosaccharomyces pombe |
| PP2B | - |
Candida albicans |
| PP2B | - |
Cryptococcus neoformans |
| PPP3 | - |
Saccharomyces cerevisiae |
| PPP3 | - |
Schizosaccharomyces pombe |
| PPP3 | - |
Candida albicans |
| PPP3 | - |
Cryptococcus neoformans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | - |
Saccharomyces cerevisiae | |
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