Literature summary for 3.1.3.16 extracted from

Tung, H.Y.L.; Alemany, S.; Cohen, P.
The protein phosphatases involved in cellular regulation. 2. Purification, subunit structure and properties of protein phosphatases-2A0, 2A1, and 2A2 from rabbit skeletal muscle (1985), Eur. J. Biochem., 148, 253-263.

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Activating Compound

Activating Compound	Comment	Organism	Structure
histone	-	Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
103000	109000	phosphatase 2A2, sedimentation equilibrium centrifugation	Oryctolagus cuniculus
177000	180000	phosphatase 2A0, sedimentation equilibrium centrifugation	Oryctolagus cuniculus
202000	-	phosphatase 2A1, sedimentation equilibrium centrifugation	Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
phosphoprotein + H2O	Oryctolagus cuniculus	capable of dephosphorylating the major proteins involved in control of glycogen metabolism, glycolysis, gluconeogenesis, aromatic amino acid breakdown, fatty acid, cholesterol, and protein synthesis	protein + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
phosphatases 2A0, 2A1, 2A2	Oryctolagus cuniculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
skeletal muscle	-	Oryctolagus cuniculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.9	2.6	-	Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphophosphorylase kinase + H2O	specific for alpha-subunit	Oryctolagus cuniculus	phosphorylase kinase + phosphate	-	?
phosphoprotein + H2O	capable of dephosphorylating the major proteins involved in control of glycogen metabolism, glycolysis, gluconeogenesis, aromatic amino acid breakdown, fatty acid, cholesterol, and protein synthesis	Oryctolagus cuniculus	protein + phosphate	-	?
phosphoproteins + H2O	-	Oryctolagus cuniculus	proteins + phosphate	-	?

Subunits

Subunits	Comment	Organism
dimer	phosphatase 2A2	Oryctolagus cuniculus
tetramer	AB'C2, phosphatase 2A0, A: 60000, B: 54000, C: 36000, rabbit, SDS-PAGE	Oryctolagus cuniculus
trimer	phosphatase 2A1	Oryctolagus cuniculus

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Release 2023.1 (January 2023)