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Literature summary for 3.1.3.16 extracted from
- Three distinct forms of type 2A protein phosphatase in human erythrocyte cytosol (1988), J. Biol. Chem., 263, 3752-3761.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| heparin | causes dissociation to alpha1, beta1 and hence stimulation | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| phosphate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 103000 | 109000 | phosphatase IV, gel filtration | Homo sapiens |
| 177000 | 180000 | phosphatase III, gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| phosphatases I, II, III, all type 2A | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 3.4 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -80°C, 50 mM Tris-HCl buffer, pH 7.4, 1 mM EDTA, 0.5 mM dithiothreitol, 0.03 M NaCl, 10% glycerol, protease inhibitor, at least 1 month | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphohistone + H2O | - |
Homo sapiens | histone + phosphate | - |
? | |
| phosphoproteins + H2O | - |
Homo sapiens | proteins + phosphate | - |
? | |
| phosphorylase a + H2O | - |
Homo sapiens | phosphorylase b + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | alpha1,beta1, or AC, alpha: 32000-40000, catalytic, beta: 58000-69000, phosphatase IV | Homo sapiens |
| trimer | alpha1, beta1,gamma1, phosphatase III | Homo sapiens |
| trimer | alpha1,beta1,delta1, phosphatase I | Homo sapiens |
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