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Literature summary for 3.1.3.11 extracted from
- Fructose-1,6-bisphosphatase opposes renal carcinoma progression (2014), Nature, 513, 251-255.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | fructose-1,6-bisphosphatase isoform FBP1 is uniformly depleted in over six hundred clear cell renal cell carcinoma tumors examined. FBP1 antagonizes glycolytic flux in renal tubular epithelial cells, the presumptive clear cell renal cell carcinoma cell of origin, thereby inhibiting a potential Warburg effect. In addition, in von Hippel-Lindau protein-deficient clear cell renal cell carcinoma cells, FBP1 restrains cell proliferation, glycolysis and the pentose phosphate pathway in a catalytic activity-independent manner, by inhibiting nuclear hypoxia-inducible factor function via direct interaction with the hypoxia-inducible factor inhibitory domain | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
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