Application | Comment | Organism |
---|---|---|
medicine | recombinant enzyme can specifically bind to the membrane of human hepatic stellate cell line LX-2 and stimulates proliferation and activation of LX-2, provoking upregulation of key fibrosis-related factors, such as alpha-smooth muscle actin, collagen I and collagen III. In infected rat, the enzyme is ubiquitously detected on the bile duct epithelial cells and the surface of hyperplastic adenoma close to the resident worms and the liver parenchyma, respectively | Clonorchis sinensis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AMP | inhibitory below 0.2 mM | Clonorchis sinensis | |
Ca2+ | unique divalent metal ion inhibitor | Clonorchis sinensis | |
Mg2+ | inhibitory above 10 mM | Clonorchis sinensis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0419 | - |
D-fructose 1,6-bisphosphate | pH 7.5, 37°C | Clonorchis sinensis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Clonorchis sinensis | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | stimulation increases in the order Mg2+, Mn2+, Zn2+, Cu2+. Mg2+ stimulates below 5 mM, inhibits above 10 mM | Clonorchis sinensis | |
Mg2+ | stimulation increases in the order Mg2+, Mn2+, Zn2+, Cu2+. Mg2+ stimulates below 5 mM, inhibits above 10 mM | Clonorchis sinensis | |
Mn2+ | stimulation increases in the order Mg2+, Mn2+, Zn2+, Cu2+. Mg2+ stimulates below 5 mM, inhibits above 10 mM | Clonorchis sinensis | |
Zn2+ | stimulation increases in the order Mg2+, Mn2+, Zn2+, Cu2+. Mg2+ stimulates below 5 mM, inhibits above 10 mM | Clonorchis sinensis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clonorchis sinensis | G7YVB4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Clonorchis sinensis | - |
larval integument | - |
Clonorchis sinensis | - |
additional information | both transcriptional and translational level are higher in metacercariae of larva stages, than those in adult worm. Ubiquitous expression in metacercariae | Clonorchis sinensis | - |
vitellarium | - |
Clonorchis sinensis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-fructose 1,6-bisphosphate + H2O | - |
Clonorchis sinensis | D-fructose 6-phosphate + phosphate | - |
? |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
15 | 45 | more than 70% of maxiumum activity | Clonorchis sinensis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | - |
Clonorchis sinensis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 9.5 | more than 80% of maxiumum activity | Clonorchis sinensis |