Cloned (Comment) | Organism |
---|---|
expression in HL-1 cardiomyocyte | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of first 7 N-terminal amino acids of isoform FBP2 markedly impairs colocalization of the enzyme with mitochondria in the presence of GSK3 inhibitor. Deletion of the next 3 residues further enhanced this effect | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00757 | isoform FBP2 | - |
Synonyms | Comment | Organism |
---|---|---|
FBP2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the quaternary structure of isoform FBP2 plays a crucial role in the binding binds to mitochondria where it interacts with proteins involved in regulation of energy homeostasis interaction. The AMP-driven transition of the FBP2 subunit arrangement from active to inactive precludes its association with the mitochondria. Truncation of the evolutionarily conserved N-terminal residues of FBP2 results in a loss of its mitochondria-protective functions | Homo sapiens |