Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.11 extracted from

  • Jardon, R.; Gancedo, C.; Flores, C.L.
    The gluconeogenic enzyme fructose-1,6-bisphosphatase is dispensable for growth of the yeast Yarrowia lipolytica in gluconeogenic substrates (2008), Eukaryot. Cell, 7, 1742-1749.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Yarrowia lipolytica Yarrowia lipolytica

Protein Variants

Protein Variants Comment Organism
additional information a Yarrowia lipolytica strain with two different disrupted versions of YlFBP1 is constructed. The mutant strain grows much slower than the wild type in gluconeogenic carbon sources but growth is not abolished due to the existance of an alternative phosphatase with a high Km for fructose-1,6-bisphosphate Yarrowia lipolytica

Inhibitors

Inhibitors Comment Organism Structure
AMP
-
Yarrowia lipolytica
fructose-2,6-bisphosphate 50% inhibition in the presence of 0.2 mM fructose-1,6-bisphosphate Yarrowia lipolytica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
D-fructose 1,6-bisphosphate
-
Yarrowia lipolytica

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Yarrowia lipolytica 5737
-
nucleus
-
Yarrowia lipolytica 5634
-

Organism

Organism UniProt Comment Textmining
Yarrowia lipolytica Q7Z8Q0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate + H2O
-
Yarrowia lipolytica D-fructose 6-phosphate + phosphate
-
?

Synonyms

Synonyms Comment Organism
fructose-1,6-bisphosphatase
-
Yarrowia lipolytica
YlFBP1
-
Yarrowia lipolytica

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.08
-
AMP
-
Yarrowia lipolytica