Literature summary for 3.1.3.11 extracted from

Gu, X.; Chen, M.; Shen, H.; Jiang, X.; Huang, Y.; Wang, H.
Rv2131c gene product: an unconventional enzyme that is both inositol monophosphatase and fructose-1,6-bisphosphatase (2006), Biochem. Biophys. Res. Commun., 339, 897-904.

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Protein Variants

Protein Variants	Comment	Organism
D40N	almost complete loss of both inositol monophosphatase and fructose 1,6-bisphosphatase activity	Mycobacterium tuberculosis
D94N	almost complete loss of both inositol monophosphatase and fructose 1,6-bisphosphatase activity	Mycobacterium tuberculosis
L71A	no loss of either of the activities, activity toward inositol is more resisitant to inhibition by calcium than wild-type	Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.45	-	fructose 1,6-bisphosphate	37°C, pH 10.0	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	recombinant enzyme, shows dual activity of both inositol monophosphatase and fructose 1,6-bisphosphatase	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-fructose 1,6-bisphosphate + H2O	-	Mycobacterium tuberculosis	D-fructose 6-phosphate + phosphate	-	?
D-fructose 1,6-bisphosphate + H2O	-	Mycobacterium tuberculosis H37Rv	D-fructose 6-phosphate + phosphate	-	?

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Release 2023.1 (January 2023)