Activating Compound | Comment | Organism | Structure |
---|---|---|---|
citrate | activates | Homo sapiens | |
EDTA | activation | Homo sapiens | |
His | activation | Homo sapiens | |
NH4+ | 0.01-0.02 mM, slight activation of neutral and alkaline isoenzyme, progressive inhibition at increasing concentration | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
K+ | at 5 mM Mg2+, increasing K+ up to 140 mM are progressively inhibitory for neutral and alkaline isoenzyme from liver, muscle neutral isoenzyme is activated, 10% at 5 mM Mg2+ but inhibited at 1 mM Mg2+ | Homo sapiens | |
NH4+ | 0.01-0.02 mM, slight activation of neutral and alkaline isoenzyme, progressive inhibition at increasing concentration | Homo sapiens | |
Zn2+ | 0.001-0.010 mM has no significant effect, with 0.002-0.0035 mM Zn2+, in absence of EDTA, 50% inhibition, 80% inhibition by 0.01 mM Zn2+ | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
fructose 1,6-diphosphate | alkaline isoenzyme | Homo sapiens | |
0.0034 | - |
fructose 1,6-diphosphate | neutral isoenzyme | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | at 5 mM Mg2+, increasing K+ up to 140 mM are progressively inhibitory for neutral and alkaline isoenzyme from liver, muscle neutral isoenzyme is activated, 10% at 5 mM Mg2+ but inhibited at 1 mM Mg2+ | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-fructose 1,6-diphosphate + H2O | Homo sapiens | the alkaline isoenzyme may have an important role in vivo in the regulation and control of glycolysis and glyconeogenesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-fructose 1,6-diphosphate + H2O | the alkaline isoenzyme may have an important role in vivo in the regulation and control of glycolysis and glyconeogenesis | Homo sapiens | ? | - |
? | |
D-fructose 1,6-diphosphate + H2O | - |
Homo sapiens | D-fructose 6-phosphate + phosphate | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
70 | - |
half-life of neutral isoenzyme: 710 s, half-life of alkaline isoenzyme: 764 s | Homo sapiens |