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Literature summary for 3.1.3.11 extracted from
- Fructose-1,6-bisphosphatase from turkey liver (1982), Methods Enzymol., 90, 334-340.
General Stability
| General Stability | Organism |
|---|---|
| immobilization on CNBr-activated Sepharose 4B, 57% loss of activity | Meleagris gallopavo |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | sensitivity decreases greatly with increasing pH or temperature. Inhibition of Zn2+ and AMP is synergistic | Meleagris gallopavo |  |
| Mg2+ | inhibits above the optimal concentration of 1-1.5 mM | Meleagris gallopavo | |
| Mn2+ | inhibits above the optimal concentration of 0.05-0.07 mM | Meleagris gallopavo | |
| Zn2+ | pH 7.5, 0.0015 mM, 92% inhibition. Inhibition of Zn2+ and AMP is synergistic | Meleagris gallopavo | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | activates | Meleagris gallopavo | |
| Mg2+ | optimal concentration at pH 7.5: 1-1.5 mM | Meleagris gallopavo | |
| Mg2+ | divalent cation required. Mn2+ or Mg2+ | Meleagris gallopavo | |
| Mn2+ | divalent cation required. Mn2+ or Mg2+ | Meleagris gallopavo | |
| Mn2+ | optimal concentration at pH 7.5: 0.05-0.07 mM | Meleagris gallopavo | |
| Tl+ | activates | Meleagris gallopavo | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36000 | - |
4 * 36000, SDS-PAGE | Meleagris gallopavo |
| 144000 | - |
sucrose density gradient centrifugation | Meleagris gallopavo |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Meleagris gallopavo | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Meleagris gallopavo |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Meleagris gallopavo | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 25.3 | - |
- |
Meleagris gallopavo |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose 1,6-diphosphate + H2O | - |
Meleagris gallopavo | D-fructose 6-phosphate + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 36000, SDS-PAGE | Meleagris gallopavo |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | 7.6 | in presence of chelating agents | Meleagris gallopavo |
| 8.4 | 8.5 | without chelating agents | Meleagris gallopavo |
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Release 2023.1 (January 2023)
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