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Literature summary for 3.1.3.1 extracted from

  • Lanier, M.; Sergienko, E.; Simao, A.M.; Su, Y.; Chung, T.; Millan, J.L.; Cashman, J.R.
    Design and synthesis of selective inhibitors of Placental Alkaline Phosphatase (2010), Bioorg. Med. Chem., 18, 573-579.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.1

Inhibitors

Inhibitors Comment Organism Structure
1-(3,4-dihydroxyphenyl)-2-(1H-imidazol-1-yl)ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-(2-ethyl-1H-imidazol-1-yl)ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-(2-methyl-1H-benzimidazol-1-yl)ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-(2-methyl-1H-imidazol-1-yl)ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-(2-phenyl-1H-imidazol-1-yl)ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-(4-methyl-1H-imidazol-1-yl)ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-(4-methyl-1H-pyrazol-1-yl)ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-(4H-1,2,4-triazol-4-yl)ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-(5,6-dimethyl-1H-benzimidazol-1-yl)ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-(propan-2-ylamino)ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-[(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]ethanone
-
 Homo sapiens
1-(3,4-dihydroxyphenyl)-2-[[1-(4-methoxyphenyl)-1H-tetrazol-5-yl]sulfanyl]ethanone
-
 Homo sapiens
2-(1H-benzimidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone
-
 Homo sapiens
2-(1H-benzimidazol-2-ylamino)-1-(3,4-dihydroxyphenyl)ethanone
-
 Homo sapiens
2-(4-bromo-1H-imidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone
-
 Homo sapiens
2-(4-bromo-2-methyl-1H-imidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone
-
 Homo sapiens
2-[[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl]-4-(methoxymethyl)-6-methylpyridine-3-carbonitrile
-
 Homo sapiens
3-[2-(3,4-dihydroxyphenyl)-2-oxoethyl]-6,7-dimethoxy-2-benzofuran-1(3H)-one
-
 Homo sapiens
4-[[(4,6-dimethylpyrimidin-2-yl)amino]methyl]benzene-1,2-diol
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 2-chloro-5-(4-methoxyspiro (1,2-dioxetane-3,2'-(5'-chloro)tricyclo[3.3.1.13,7]decan)-4-yl)phenyl phosphate
-
 Homo sapiens
0.085
-
 2-chloro-5-(4-methoxyspiro (1,2-dioxetane-3,2'-(5'-chloro)tricyclo[3.3.1.13,7]decan)-4-yl)phenyl phosphate
-
 Homo sapiens
0.177
-
 2-chloro-5-(4-methoxyspiro (1,2-dioxetane-3,2'-(5'-chloro)tricyclo[3.3.1.13,7]decan)-4-yl)phenyl phosphate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Homo sapiens
-
germ cell
-
 Homo sapiens
-
intestine
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
syncytiotrophoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-chloro-5-(4-methoxyspiro (1,2-dioxetane-3,2'-(5'-chloro)tricyclo[3.3.1.13,7]decan)-4-yl)phenyl phosphate + H2O CDP-star Homo sapiens 2-chloro-5-(4-methoxyspiro (1,2-dioxetane-3,2'-(5'-chloro)tricyclo[3.3.1.13,7]decan)-4-yl)phenol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
germ cell alkaline phosphatase
-
 Homo sapiens
intestinal alkaline phosphatase
-
 Homo sapiens
placental alkaline phosphatase
-
 Homo sapiens
tissue-nonspecific alkaline phosphatase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0006
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]ethanone
0.0008
-
-
 Homo sapiens 2-(1H-benzimidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone
0.0012
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(1H-imidazol-1-yl)ethanone
0.0012
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(2-methyl-1H-benzimidazol-1-yl)ethanone
0.002
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-[[1-(4-methoxyphenyl)-1H-tetrazol-5-yl]sulfanyl]ethanone
0.0021
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(1H-imidazol-1-yl)ethanone
0.0022
-
-
 Homo sapiens 2-[[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl]-4-(methoxymethyl)-6-methylpyridine-3-carbonitrile
0.0025
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]ethanone
0.0027
-
-
 Homo sapiens 2-(1H-benzimidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone
0.0027
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(4-methyl-1H-pyrazol-1-yl)ethanone
0.003
-
-
 Homo sapiens 3-[2-(3,4-dihydroxyphenyl)-2-oxoethyl]-6,7-dimethoxy-2-benzofuran-1(3H)-one
0.0033
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(2-methyl-1H-imidazol-1-yl)ethanone
0.0042
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(2-ethyl-1H-imidazol-1-yl)ethanone
0.0048
-
-
 Homo sapiens 2-[[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl]-4-(methoxymethyl)-6-methylpyridine-3-carbonitrile
0.0049
-
-
 Homo sapiens 2-(4-bromo-2-methyl-1H-imidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone
0.0058
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(4-methyl-1H-imidazol-1-yl)ethanone
0.0058
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(5,6-dimethyl-1H-benzimidazol-1-yl)ethanone
0.0062
-
-
 Homo sapiens 2-(1H-benzimidazol-2-ylamino)-1-(3,4-dihydroxyphenyl)ethanone
0.0067
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-[(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]ethanone
0.008
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-[[1-(4-methoxyphenyl)-1H-tetrazol-5-yl]sulfanyl]ethanone
0.0086
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]ethanone
0.0087
-
-
 Homo sapiens 2-(4-bromo-2-methyl-1H-imidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone
0.0091
-
-
 Homo sapiens 2-(1H-benzimidazol-2-ylamino)-1-(3,4-dihydroxyphenyl)ethanone
0.0134
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(4H-1,2,4-triazol-4-yl)ethanone
0.0148
-
-
 Homo sapiens 2-(1H-benzimidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone
0.0158
-
-
 Homo sapiens 2-(4-bromo-1H-imidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone
0.0172
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(2-phenyl-1H-imidazol-1-yl)ethanone
0.018
-
-
 Homo sapiens 2-(1H-benzimidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone
0.0263
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(2-methyl-1H-benzimidazol-1-yl)ethanone
0.0292
-
-
 Homo sapiens 3-[2-(3,4-dihydroxyphenyl)-2-oxoethyl]-6,7-dimethoxy-2-benzofuran-1(3H)-one
0.0302
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(1H-imidazol-1-yl)ethanone
0.0393
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(propan-2-ylamino)ethanone
0.0411
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(4-methyl-1H-imidazol-1-yl)ethanone
0.0475
-
-
 Homo sapiens 2-(4-bromo-1H-imidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone
0.0495
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]ethanone
0.0512
-
-
 Homo sapiens 4-[[(4,6-dimethylpyrimidin-2-yl)amino]methyl]benzene-1,2-diol
0.0533
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(4-methyl-1H-pyrazol-1-yl)ethanone
0.0646
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(2-methyl-1H-imidazol-1-yl)ethanone
0.0783
-
-
 Homo sapiens 1-(3,4-dihydroxyphenyl)-2-(2-methyl-1H-imidazol-1-yl)ethanone
0.0938
-
-
 Homo sapiens 2-(1H-benzimidazol-2-ylamino)-1-(3,4-dihydroxyphenyl)ethanone