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Literature summary for 3.1.3.1 extracted from

  • Chida, K.; Taguchi, M.
    Change in localization of alkaline phosphatase and mannosidase II by colchicine treatment of primary cultures of fetal rat hepatocytes (2008), Acta Histochem. Cytochem., 41, 1-5.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
molecular biology colchicine inhibits the dexamethasone-promoted translocation of ALP to the plasma membrane surrounding the bile canaliculus-like structure in primary cultures of fetal rat hepatocytes by disassembling microtubules and discomposing the Golgi complex Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus 5737
-
additional information in hepatocytes cultured in the same medium containing colchicine, the structure of microtubules in the cytoplasm is lost, ALP is localized in coarse granular sites of the cytoplasm Rattus norvegicus
-
-
perinuclear space
-
Rattus norvegicus
-
-
perinuclear space in hepatocytes cultured in basal medium, ALP is localized in the perinuclear cytoplasm Rattus norvegicus
-
-
plasma membrane when hepatocytes are cultured in dexamethasone-supplemented medium, ALP is also localized in the plasma membrane surrounding the bile canaliculus-like structure that is formed between adjacent cells Rattus norvegicus 5886
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plasma membrane hepatocytes cultured in dexamethason-supplemented medium Rattus norvegicus 5886
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specific granule hepatocytes cultured in colchicine-containing medium Rattus norvegicus 42581
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte fetal Rattus norvegicus
-
hepatocyte primary cultures of fetal rat hepotocytes are used Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
alkaline phosphatase
-
Rattus norvegicus
ALP
-
Rattus norvegicus