Application | Comment | Organism |
---|---|---|
molecular biology | colchicine inhibits the dexamethasone-promoted translocation of ALP to the plasma membrane surrounding the bile canaliculus-like structure in primary cultures of fetal rat hepatocytes by disassembling microtubules and discomposing the Golgi complex | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
additional information | in hepatocytes cultured in the same medium containing colchicine, the structure of microtubules in the cytoplasm is lost, ALP is localized in coarse granular sites of the cytoplasm | Rattus norvegicus | - |
- |
perinuclear space | - |
Rattus norvegicus | - |
- |
perinuclear space | in hepatocytes cultured in basal medium, ALP is localized in the perinuclear cytoplasm | Rattus norvegicus | - |
- |
plasma membrane | when hepatocytes are cultured in dexamethasone-supplemented medium, ALP is also localized in the plasma membrane surrounding the bile canaliculus-like structure that is formed between adjacent cells | Rattus norvegicus | 5886 | - |
plasma membrane | hepatocytes cultured in dexamethason-supplemented medium | Rattus norvegicus | 5886 | - |
specific granule | hepatocytes cultured in colchicine-containing medium | Rattus norvegicus | 42581 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | fetal | Rattus norvegicus | - |
hepatocyte | primary cultures of fetal rat hepotocytes are used | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
alkaline phosphatase | - |
Rattus norvegicus |
ALP | - |
Rattus norvegicus |