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Literature summary for 3.1.3.1 extracted from

  • Nishioka, T.; Tomatsu, S.; Gutierrez, M.A.; Miyamoto, K.I.; Trandafirescu, G.G.; Lopez, P.L.; Grubb, J.H.; Kanai, R.; Kobayashi, H.; Yamaguchi, S.; Gottesman, G.S.; Cahill, R.; Noguchi, A.; Sly, W.S.
    Enhancement of drug delivery to bone: Characterization of human tissue-nonspecific alkaline phosphatase tagged with an acidic oligopeptide (2006), Mol. Genet. Metab., 88, 244-255.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine hypophosphatasia is caused by deficiency of activity of the tissue-nonspecific alkaline phosphatase, resulting in a defect of bone mineralization. Anchorless enzymes tagged with an acidic oligopeptide are delivered efficiently to bone and function bioactively in bone mineralization, at least in vivo. Potential advantages for use of these tagged enzymes in enzyme replacement theraphy for hypophosphatasia Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens hypophosphatasia is caused by deficiency of activity of the tissue-nonspecific alkaline phosphatase, resulting in a defect of bone mineralization ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information hypophosphatasia is caused by deficiency of activity of the tissue-nonspecific alkaline phosphatase, resulting in a defect of bone mineralization Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
tissue-nonspecific alkaline phosphatase
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Homo sapiens
TNSALP
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Homo sapiens