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Literature summary for 3.1.3.1 extracted from
- Characterization and localization of alkaline phosphatase in canine seminal plasma and gonadal tissues (2003), Theriogenology, 60, 299-306.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | the enzyme is a useful marker of the sperm-rich fraction of the ejaculate | Canis lupus familiaris |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| levamisole | complete inhibition of the seminal plasma enzyme at 4.2 mM | Canis lupus familiaris |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
beagle and mixed breed, 2 genes encoding 2 isozyme types: a tissue non-specific isozyme and an intestinal isozyme | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | sialic acid containing carbohydrates, different pattern for the different isozymes | Canis lupus familiaris |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| a phosphate monoester + H2O = an alcohol + phosphate | Wide specificity. Also catalyses transphosphorylations. Some enzymes hydrolyse diphosphate | Canis lupus familiaris |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | contains liver and bone isozymes | Canis lupus familiaris | - |
| bone | bone isozyme is of the non-specific type | Canis lupus familiaris | - |
| epididymis | fluid, high activity, secretion of the enzyme, localized to caput, corpora, and cauda | Canis lupus familiaris | - |
| epithelium | epididymal and seminiferous tubular epithelium, seminal plasma isozyme is of the non-specific type, secretion of the enzyme, no activity in the basal membrane of the epididymal epithelial cells | Canis lupus familiaris | - |
| intestine | intestinal isozyme type | Canis lupus familiaris | - |
| liver | liver isozyme is of the non-specific type | Canis lupus familiaris | - |
| additional information | tissue distribution, 2 isozyme types: a tissue non-specific isozyme and an intestinal isozyme type, different forms of these isozymes are bone, liver, seminal plasma and kidney enzymes of the non-specific type, and intestine and corticosteroid-inducible enzymes of the intestinal type | Canis lupus familiaris | - |
| osteosarcoma cell | bone isozyme is of the non-specific type | Canis lupus familiaris | - |
| prostate | low activity | Canis lupus familiaris | - |
| seminal plasma | seminal plasma specific isozyme of the non-specific type | Canis lupus familiaris | - |
| serum | - |
Canis lupus familiaris | - |
| sperm | - |
Canis lupus familiaris | - |
| testis | low activity, localized on the surface of the seminiferous epithelial cells and tubules | Canis lupus familiaris | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity in different tissue and fluid samples | Canis lupus familiaris |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-bromo-4-chloro-3-indolyl phosphate + nitroblue tetrazolium | i.e. BCIP/NBT system | Canis lupus familiaris | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alkaline phosphatase | - |
Canis lupus familiaris |
| AP | - |
Canis lupus familiaris |
| SAP | - |
Canis lupus familiaris |
| seminal plasma alkaline phosphatase | - |
Canis lupus familiaris |
| seminal plasma AP | - |
Canis lupus familiaris |
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