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Literature summary for 3.1.26.4 extracted from

  • Sparks, J.L.; Chon, H.; Cerritelli, S.M.; Kunkel, T.A.; Johansson, E.; Crouch, R.J.; Burgers, P.M.
    RNase H2-initiated ribonucleotide excision repair (2012), Mol. Cell, 47, 980-986.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.26.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RNA-DNA hybrid + H2O Saccharomyces cerevisiae RNase H2 incises the DNA 5'-of the ribonucleotide, generating DNA containing 3'-hydroxyl and 5'-phosphoribonucleotide ends ribonucleotide 5'-phosphomonoester
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RNA-DNA hybrid + H2O RNase H2 incises the DNA 5'-of the ribonucleotide, generating DNA containing 3'-hydroxyl and 5'-phosphoribonucleotide ends Saccharomyces cerevisiae ribonucleotide 5'-phosphomonoester
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 ?

Synonyms

Synonyms Comment Organism
ribonuclease H1
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 Saccharomyces cerevisiae
ribonuclease H2
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 Saccharomyces cerevisiae
RNase H1
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 Saccharomyces cerevisiae
RNase H2
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function ribonucleotide excision repair is most efficient when the ribonucleotide is incised by RNase H2. RNase H1 fails to substitute for RNase H2 in the incision step of ribonucleotide excision repair Saccharomyces cerevisiae